Battermann J J, Tierie A H
Radiother Oncol. 1986 Feb;5(2):85-90. doi: 10.1016/s0167-8140(86)80161-x.
In the period from January 1972 through December 1983 a total of 123 patients was treated for a bladder malignancy by preoperative external irradiation followed by interstitial therapy. Criteria for selection of patients are solitary lesion, tumour smaller than 5 cm in diameter, state T1 and T2. The majority of patients was in state T2 (89 patients). Persisting local control was achieved in 29 out of 34 T1 cases and in 69 out of 85 T2 cases. The actuarial 10 years survival was 72% for T1 and 34% for T2, with a total disease-free percentage at 10 years of 77% for T1 and 56% for T2. Although in many patients delayed wound healing was noticed, no serious late reactions were seen in skin, bladder or intestine. The causes of death are distant metastases in 13 patients and intercurrent diseases in another 21 patients.
在1972年1月至1983年12月期间，共有123例膀胱恶性肿瘤患者接受了术前体外照射加组织间治疗。患者选择标准为单发病变、肿瘤直径小于5 cm、T1和T2期。大多数患者处于T2期（89例）。34例T1期病例中有29例实现了局部持续控制，85例T2期病例中有69例实现了局部持续控制。T1期的10年精算生存率为72%，T2期为34%，T1期10年的无病总百分比为77%，T2期为56%。尽管在许多患者中发现伤口愈合延迟，但在皮肤、膀胱或肠道中未观察到严重的晚期反应。死亡原因是13例远处转移和另外21例并发疾病。
