Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ont.; Toronto Eyelid, Strabismus & Orbit Surgery Clinic, Toronto, Ont..
Department of Ophthalmology, Queens University, Kingston, Ont.
Can J Ophthalmol. 2019 Feb;54(1):119-124. doi: 10.1016/j.jcjo.2018.03.002. Epub 2018 Nov 12.
The incidence of giant cell arteritis (GCA) is insufficiently documented for Canada, but important to ascertain for public health planning. We estimate the incidence of biopsy-proven GCA (BPGCA) in Kingston, Ontario, and for the province of Ontario.
The number of cases of BPGCA was tabulated from retrospective chart review of all temporal artery biopsies (TABx) in Kingston, Ontario from 2011-15. The relevant population denominator was determined from the Canada census federal electoral district and the patient's postal code. The province-wide estimate for the incidence of BPGCA was calculated from provincial billing data of TABx from 2015-17, the Canada census for Ontario, and the expected positive yield of TABx.
There were 35 subjects with BPGCA in the Kingston area over the 4-year period, from a population of 179 503 individuals 50 years of age or older (≥50 years). Ontario billing data identified 2404 patients who underwent TABx for suspected GCA over a 2-year period, from a population of 5 143 610 persons ≥50 years. Meta-analysis of 5 provincial TABx series suggested a 21% positive yield from TABx procedures (95% CI 0.18-0.24). The minimum cumulative incidence of BPGCA was 4.9 per 100 000 persons ≥50 years in Kingston, and 4.9 (95% CI 4.2-5.6) per 100 000 persons ≥50 years for Ontario as a whole.
The estimated incidence of BPGCA in Ontario using 2 different estimation techniques was comparable, but low compared with other countries. The actual incidence of GCA in Ontario may be higher.
加拿大的巨细胞动脉炎（GCA）发病率记录不足，但对公共卫生规划很重要。我们估计安大略省金斯敦活检证实的 GCA（BPGCA）的发病率，并估计安大略省的 GCA 发病率。
从 2011 年至 2015 年对安大略省金斯敦所有颞动脉活检（TABx）的回顾性图表审查中，列出了 BPGCA 的病例数。相关的人口分母是根据加拿大人口普查的联邦选区和患者的邮政编码确定的。通过 2015 年至 2017 年的 TABx 省级计费数据、安大略省的加拿大人口普查以及 TABx 的预期阳性率，计算出全省范围内 BPGCA 的发病率。
在 4 年期间，金斯敦地区有 35 名 BPGCA 患者，年龄在 50 岁或以上（≥50 岁）的人口为 179503 人。安大略省的计费数据确定了 2404 名患者在 2 年内因疑似 GCA 接受了 TABx，年龄在 50 岁或以上的人口为 5143610 人。对 5 个省级 TABx 系列的荟萃分析表明，TABx 程序的阳性率为 21%（95%CI 0.18-0.24）。金斯敦≥50 岁人群中 BPGCA 的最低累积发病率为每 100000 人 4.9 例，安大略省≥50 岁人群中每 100000 人 4.9（95%CI 4.2-5.6）例。
使用 2 种不同的估计技术估计安大略省的 BPGCA 发病率相似，但与其他国家相比较低。安大略省 GCA 的实际发病率可能更高。
