Anderson William J, Jo Vickie Y
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States.
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States.
Semin Diagn Pathol. 2019 Mar;36(2):122-128. doi: 10.1053/j.semdp.2019.02.007. Epub 2019 Feb 28.
Pleomorphic liposarcoma is the least common but most aggressive subtype of liposarcoma. Tumors most commonly arise in the deep soft tissues of the extremities in adult patients. Pleomorphic liposarcoma has no specific immunohistochemical or molecular genetic features, and the presence of lipoblasts remains the sole diagnostic criterion. Diagnostic challenges include the identification of lipoblasts, which are often scarce or focal, and the distinction from other pleomorphic sarcomas, including dedifferentiated liposarcoma with homologous lipoblastic differentiation. This review provides an updated overview of the clinicopathologic features of pleomorphic liposarcoma, with discussion of its morphologic variants, differential diagnosis, and the role of small biopsy samples.
多形性脂肪肉瘤是脂肪肉瘤中最不常见但最具侵袭性的亚型。肿瘤最常发生于成年患者四肢的深部软组织。多形性脂肪肉瘤没有特异性的免疫组化或分子遗传学特征，脂母细胞的存在仍然是唯一的诊断标准。诊断挑战包括识别脂母细胞，脂母细胞通常稀少或呈局灶性，以及与其他多形性肉瘤相鉴别，包括具有同源性脂母细胞分化的去分化脂肪肉瘤。本综述提供了多形性脂肪肉瘤临床病理特征的最新概述，并讨论了其形态学变异、鉴别诊断以及小活检样本的作用。
