Sukkari M Walid, Ebedo Raghad, Hulou Saad, Shami Besher, Nastah Samer, Sabbagh Aziz
Faculty of Medicine, University of Aleppo.
Department of Surgical Oncology, Aleppo University Hospital.
Ann Med Surg (Lond). 2024 Sep 10;86(10):6317-6321. doi: 10.1097/MS9.0000000000002560. eCollection 2024 Oct.
Retroperitoneal liposarcomas (RPLPSs) are rare tumors that arise from mesenchymal cells in the peritoneum cavity. The sites of PRLPSs vary a lot, but renal PRLPSs are extremely rare (there are only 45 cases of Renal retroperitoneal liposarcomas on PubMed). In this case, the authors present a rare renal retroperitoneal liposarcoma case, describe the major concepts, and raise awareness about this rare tumor.
A 44-year-old woman presented to the clinic with hirsutism and irregular menstruation; upon physical examination, a large abdominal mass was accidentally identified; the patient had Doppler ultrasound (Doppler US) and MRI, which both showed a mass arising from the right upper pole of the kidney, fine needle aspiration (FNA) confirmed the diagnosis of retroperitoneal liposarcoma, patient underwent surgical removal and her symptoms disappeared.
The retroperitoneum is a cavity behind the abdominal wall containing organs like the pancreas and kidneys. Retroperitoneal tumors (RPTs) are rare neoplasms, primarily of mesenchymal origin. Retroperitoneal liposarcomas (RPLPS) are the most common RPT, often asymptomatic until large, and rarely metastasize but frequently recur. Liposarcomas are classified into five subtypes, with well-differentiated liposarcoma being the most common and characterized by high local recurrence. The presence of specific oncologic mutations affects the prognosis and the response to treatment.
In rare cases, retroperitoneal liposarcomas can arise from sites near the kidney and compress the adjoining adrenal gland.
腹膜后脂肪肉瘤（RPLPS）是起源于腹膜腔间充质细胞的罕见肿瘤。PRLPS的发病部位差异很大，但肾PRLPS极为罕见（在PubMed上仅有45例肾腹膜后脂肪肉瘤病例）。在此病例中，作者呈现了一例罕见的肾腹膜后脂肪肉瘤病例，阐述了主要概念，并提高对这种罕见肿瘤的认识。
一名44岁女性因多毛症和月经不规律前往诊所就诊；体格检查时意外发现一个较大的腹部肿块；患者接受了多普勒超声（Doppler US）和MRI检查，两者均显示肿块起源于右肾上极，细针穿刺抽吸活检（FNA）确诊为腹膜后脂肪肉瘤，患者接受了手术切除，症状消失。
腹膜后是腹壁后方的一个腔隙，包含胰腺和肾脏等器官。腹膜后肿瘤（RPT）是罕见肿瘤，主要起源于间充质。腹膜后脂肪肉瘤（RPLPS）是最常见的RPT，通常在肿瘤较大之前无症状，很少发生转移，但经常复发。脂肪肉瘤分为五个亚型，高分化脂肪肉瘤最为常见，其特点是局部复发率高。特定肿瘤突变的存在会影响预后和对治疗的反应。
在罕见情况下，腹膜后脂肪肉瘤可起源于肾脏附近部位并压迫相邻的肾上腺。
