Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Trends Mol Med. 2019 Apr;25(4):261-264. doi: 10.1016/j.molmed.2019.02.009. Epub 2019 Mar 6.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer for which therapeutic options are very limited. A new study (Augert et al. Sci. Signal. 2019;12:eaau2922) shows that inhibition of the LSD1 demethylase can induce derepression of NOTCH receptor genes and subsequent activation of the NOTCH pathway, potently suppressing the growth of SCLC.
小细胞肺癌（SCLC）是一种侵袭性肺癌，治疗选择非常有限。一项新的研究（Augert 等人，《科学信号》，2019 年；12：eaau2922）表明，抑制 LSD1 去甲基酶可以诱导 NOTCH 受体基因的去抑制，并随后激活 NOTCH 途径，有力地抑制 SCLC 的生长。
