将小细胞肺癌（SCLC）的 LSD（1）之旅再推进一步 Notch 途径。
Taking SCLC on a Bad LSD(1) Trip One NOTCH Further.
机构信息
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Department of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
出版信息
Trends Mol Med. 2019 Apr;25(4):261-264. doi: 10.1016/j.molmed.2019.02.009. Epub 2019 Mar 6.
Abstract
Small cell lung cancer (SCLC) is an aggressive form of lung cancer for which therapeutic options are very limited. A new study (Augert et al. Sci. Signal. 2019;12:eaau2922) shows that inhibition of the LSD1 demethylase can induce derepression of NOTCH receptor genes and subsequent activation of the NOTCH pathway, potently suppressing the growth of SCLC.
摘要
小细胞肺癌（SCLC）是一种侵袭性肺癌，治疗选择非常有限。一项新的研究（Augert 等人，《科学信号》，2019 年；12：eaau2922）表明，抑制 LSD1 去甲基酶可以诱导 NOTCH 受体基因的去抑制，并随后激活 NOTCH 途径，有力地抑制 SCLC 的生长。
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本文引用的文献
1
2017-2018 Scientific Advances in Thoracic Oncology: Small Cell Lung Cancer.2017-2018 年胸肿瘤学的科学进展：小细胞肺癌。
J Thorac Oncol. 2019 May;14(5):768-783. doi: 10.1016/j.jtho.2019.01.022. Epub 2019 Feb 11.
2
Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.从人类胚胎干细胞生成肺神经内分泌细胞和小细胞肺癌样肿瘤。
J Exp Med. 2019 Mar 4;216(3):674-687. doi: 10.1084/jem.20181155. Epub 2019 Feb 8.
3
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.通过 LSD1 抑制靶向小细胞肺癌中的 NOTCH 激活。
Sci Signal. 2019 Feb 5;12(567):eaau2922. doi: 10.1126/scisignal.aau2922.
4
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.大细胞神经内分泌癌的综合基因组分析揭示了高级别神经内分泌肺肿瘤的不同亚型。
Nat Commun. 2018 Mar 13;9(1):1048. doi: 10.1038/s41467-018-03099-x.
5
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.Notch信号传导产生的肿瘤内异质性促进小细胞肺癌。
Nature. 2017 May 18;545(7654):360-364. doi: 10.1038/nature22323. Epub 2017 May 10.
6
Notch signalling in context.Notch 信号通路在语境中的作用。
Nat Rev Mol Cell Biol. 2016 Nov;17(11):722-735. doi: 10.1038/nrm.2016.94. Epub 2016 Aug 10.
7
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Epigenomics. 2016 Aug;8(8):1103-16. doi: 10.2217/epi-2016-0009. Epub 2016 Aug 1.
8
Comprehensive genomic profiles of small cell lung cancer.全面基因组分析小细胞肺癌
Nature. 2015 Aug 6;524(7563):47-53. doi: 10.1038/nature14664. Epub 2015 Jul 13.
9
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Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14788-93. doi: 10.1073/pnas.1410419111. Epub 2014 Sep 29.
10
Notch in lung development and lung cancer.Notch在肺发育和肺癌中的作用
Semin Cancer Biol. 2004 Oct;14(5):357-64. doi: 10.1016/j.semcancer.2004.04.015.
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