Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy; Department of Urology, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Division of Experimental Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy.
Sex Med Rev. 2020 Oct;8(4):622-634. doi: 10.1016/j.sxmr.2018.11.008. Epub 2019 Mar 7.
Previous studies have shown a strong association between diabetes mellitus (DM) and the frequency and severity of some aspects of male sexual dysfunction (SD). The same relationship with prediabetes (preDM) has been less well investigated.
To systematically review the current literature on the association between preDM and SD, focusing on erectile dysfunction (ED), sex steroid hormone alterations, and premature ejaculation (PE).
The present review was conducted in accordance with the PRISMA declaration standards for systematic reviews. A systematic search for the terms "male sexual dysfunction," "prediabetes," "IFG or IGT," "glycemia," "ED," "ejaculation," and "hypoactive sexual desire disorder" was carried out in the PubMed and Embase databases.
Prevalence of SD in men with preDM and severity of ED, PE, and hormone alterations in men with preDM compared with controls.
12 studies reporting data on the association between SD and preDM were found in the literature. According to these studies, ED is more prevalent in men with preDM compared with controls, the severity of ED increases progressively as a function of impaired glucose metabolism, testosterone values and preDM are strongly correlated, men with preDM are at increased risk of testosterone deficiency and hypogonadism, men with hypogonadism have a higher prevalence of preDM, and the association between PE and preDM is controversial.
PreDM is a common and underdiagnosed clinical condition that is strongly associated with male SD. A detailed glucose metabolism investigation should be performed in every patient with SD to screen for glucose abnormalities and eventually to implement prevention program to decrease their chances of developing life-changing chronic illnesses. Boeri L, Capogrosso P, Ventimiglia E, et al. Sexual Dysfunction in Men with Prediabetes. Sex Med Rev 2019;8:622-634.
先前的研究表明，糖尿病（DM）与男性性功能障碍（SD）的某些方面的频率和严重程度之间存在很强的关联。而对于前驱糖尿病（preDM）与 SD 之间的关系，研究则相对较少。
系统回顾目前关于前驱糖尿病与 SD 的文献，重点关注勃起功能障碍（ED）、性激素激素改变和早泄（PE）。
本综述根据系统评价的 PRISMA 声明标准进行。在 PubMed 和 Embase 数据库中，系统地搜索了“男性性功能障碍”、“前驱糖尿病”、“IFG 或 IGT”、“血糖”、“ED”、“射精”和“性欲低下障碍”等术语。
前驱糖尿病男性的 SD 患病率，以及前驱糖尿病男性与对照组相比 ED 的严重程度、PE 和激素改变。
文献中发现了 12 项关于 SD 与前驱糖尿病之间关联的研究。根据这些研究，前驱糖尿病男性的 ED 患病率高于对照组，随着葡萄糖代谢受损的加重，ED 的严重程度逐渐增加，睾酮值与前驱糖尿病密切相关，前驱糖尿病男性发生睾酮缺乏和性腺功能减退的风险增加，性腺功能减退男性的前驱糖尿病患病率较高，PE 与前驱糖尿病之间的关系存在争议。
前驱糖尿病是一种常见且未被诊断的临床病症，与男性 SD 密切相关。应对每一位 SD 患者进行详细的葡萄糖代谢检查，以筛查血糖异常，并最终实施预防计划，降低他们患改变生活的慢性疾病的风险。Boeri L、Capogrosso P、Ventimiglia E 等人。前驱糖尿病男性的性功能障碍。性医学评论 2019；8：622-634。
