Division of Experimental Oncology/Unit of Urology, URI; IRCCS Ospedale San Raffaele, Milan, Italy.
Department of Neurosciences, Reproductive Sciences and Odontostomatology, Urology Unit, University of Naples "Federico II", Naples, Italy.
Int J Impot Res. 2023 Sep;35(6):558-563. doi: 10.1038/s41443-022-00601-4. Epub 2022 Aug 1.
Concomitant sexual disorders have progressively shown increased prevalence in men at first outpatient presentation. We sought to i) estimate the prevalence of unreported premature ejaculation (PE) in a homogenous cohort of 1258 men seeking first medical help for erectile dysfunction (ED) as their primary compliant; ii) compare the baseline sociodemographic and clinical characteristics of men with only ED(ED-only) compared to those with ED and PE(ED + PE); and, iii) investigate the likelihood of detecting PE among men self-reporting only ED over a 16-year period at a single tertiary-referral centre. Descriptive statistics compared sociodemographic and clinical characteristics between ED-only patients and those with unreported concomitant primary/secondary PE(ED + PE). Logistic regression models predicted the risk of having ED + PE at baseline. Local polynomial regression models graphically explored the probability of reporting PE among ED men with ≤40 vs. 41-60 vs. >60 years over the analysed timeframe. Of all, 932 (74.1%) were ED-only and 326 (25.9%) ED + PE patients, respectively. ED + PE patients were younger, presented with fewer comorbidities, and lower rates of severe ED (all p ≤ 0.04). At multivariable logistic regression analysis, younger age (OR:0.98) and low sexual desire/interest (OR:1.54) were independently associated with ED + PE at first clinical assessment (all p = 0.03). The likelihood of detecting unreported concomitant primary/secondary PE among patients complaining of only ED at first presentation worrisomely increased among younger and middle-aged men over the last 16 years.
在首次门诊就诊时，男性同时存在的性功能障碍逐渐显示出更高的患病率。我们旨在：i）评估 1258 名因勃起功能障碍（ED）首次寻求医疗帮助而主要抱怨的男性中未报告的早泄（PE）的患病率；ii）比较仅 ED（ED-仅）的男性与同时存在 ED 和 PE（ED+PE）的男性的基线社会人口统计学和临床特征；iii）在单中心三级转诊中心，调查在 16 年期间仅报告 ED 的男性中检测 PE 的可能性。描述性统计比较 ED-仅患者和未报告同时存在原发性/继发性 PE（ED+PE）的患者的社会人口统计学和临床特征。逻辑回归模型预测基线时存在 ED+PE 的风险。局部多项式回归模型以图形方式探索在分析期间报告 PE 的 ED 男性中，≤40 岁、41-60 岁和>60 岁的可能性。共有 932 名（74.1%）为 ED-仅患者，326 名（25.9%）为 ED+PE 患者。ED+PE 患者年龄较小，合并症较少，严重 ED 的发生率较低（所有 p≤0.04）。多变量逻辑回归分析显示，年龄较小（OR：0.98）和性欲/兴趣低（OR：1.54）与首次临床评估时的 ED+PE 独立相关（所有 p=0.03）。在过去 16 年中，仅因 ED 首次就诊的患者中未报告同时存在原发性/继发性 PE 的可能性，在年轻和中年男性中令人担忧地增加。
