不动杆菌 S27 对 5-羟甲基糠醛的生物转化及其呋喃衍生物的合成。
Biotransformation of 5-hydroxymethylfurfural by Acinetobacter oleivorans S27 for the synthesis of furan derivatives.
机构信息
Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, Kerala, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram 695 019, Kerala, India.
Institute of Bioresources and Sustainable Development, Sikkim Centre, Tadong - 737102, Gangtok, Sikkim, India.
出版信息
Bioresour Technol. 2019 Jun;282:88-93. doi: 10.1016/j.biortech.2019.02.125. Epub 2019 Mar 1.
Hydroxymethylfurfural (HMF) is an industrially important chemical which is a starting material in the production of plenty of platform chemicals. In this study, a complete biotransformation of HMF was achieved using a novel isolate, Acinetobacter oleivorans S27. This strain could tolerate up to 3000 mg/L of HMF concentration and convert to other furan derivatives. The conversion products includes high-value chemicals like 5-hydroxymethyl-2-furancarboxylic acid (HMFCA), a known interleukin inhibitor and 2,5-furan dicarboxylic acid (FDCA), an alternate of terephthalic acid in polyester industries. The biotransformation efficiency was found to be 100%, as there is complete conversion of HMF to other chemicals. Most importantly, it is an environmental friendly process for the production of furan derivatives.
羟甲基糠醛（HMF）是一种具有工业重要性的化学品，是许多平台化学品生产的起始原料。在本研究中，一种新型分离物不动杆菌 oleivorans S27 实现了 HMF 的完全生物转化。该菌株能够耐受高达 3000mg/L 的 HMF 浓度，并转化为其他呋喃衍生物。转化产物包括高价值化学品，如 5-羟甲基-2-糠酸（HMFCA），一种已知的白细胞介素抑制剂和 2,5-呋喃二甲酸（FDCA），聚酯工业中对苯二甲酸的替代品。生物转化效率被发现为 100%，因为 HMF 完全转化为其他化学品。最重要的是，这是一种生产呋喃衍生物的环保工艺。
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