Wenguang Wei, Huifang Zhang, Guiwen Wu, Zhentie Yang, Rui Han
Acupuncture and Moxibustion Department, The First People's Hospital of Changzhou, Changzhou, China.
Pharmacy Department, The First People's Hospital of Changzhou, Changzhou, China.
Pak J Pharm Sci. 2019 Jan;32(1(Special)):465-469.
.This study was designed to investigate the curative effect of traditional Chinese medicine Zhiyi decoction combined with acupuncture in the treatment of enuresis and its influence on serum ADH and inflammatory factors. A total of 84 enuresis patients treated were selected as cases from September 2014 to January 2017, randomly divided into study and control group with 42 cases each. The control group was treated with traditional Chinese medicine Zhiyi decoction while the study group was treated with traditional Chinese medicine Zhiyi decoction combined with acupuncture. The clinical efficacy and levels of serum ADH, serum inflammatory factors (TNF-α and IL-6) were compared between two groups before and after treatment. In study group, there were 34 cases cured and 5 cases were improved. Total effective rate was 92.9% and recurrence rate was 4%. In control group, there were 23 and 7 cases cured and improved respectively. Total effective rate was 71.4% and recurrence rate was 14.3%. The total efficiency of study group was significantly higher than that of control group (P<0.05), and the recurrence rate was significantly lower than control group (P<0.05). After treatment, there was no significant change in ADH level of study group at 10am and 11pm (P>0.05). In control group, the level of ADH at 11pm before treatment was lower than that after treatment (P<0.05) and the level of ADH at 10am before treatment was not significantly different from that after treatment (P>0.05). The levels of serum TNF-α and IL-6 in study group and control group decreased at 10am and 11pm after treatment (P<0.05) There was no significant difference in serum TNF-α and IL-6 levels between study group and control group before treatment (P>0.05). Compared with simple acupuncture, traditional Chinese medicine Zhiyi decoction combined with acupuncture of children had more exact effect, changed enuresis symptoms effectively.
本研究旨在探讨中药止遗汤联合针刺治疗遗尿症的疗效及其对血清抗利尿激素（ADH）和炎症因子的影响。选取2014年9月至2017年1月期间收治的84例遗尿症患者作为研究对象，随机分为研究组和对照组，每组各42例。对照组采用中药止遗汤治疗，研究组采用中药止遗汤联合针刺治疗。比较两组治疗前后的临床疗效、血清ADH水平及血清炎症因子（TNF-α和IL-6）水平。研究组中，治愈34例，好转5例，总有效率为92.9%，复发率为4%。对照组中，治愈23例，好转7例，总有效率为71.4%，复发率为14.3%。研究组的总有效率显著高于对照组（P<0.05），复发率显著低于对照组（P<0.05）。治疗后，研究组上午10点和晚上11点的ADH水平无显著变化（P>0.05）。对照组治疗前晚上11点的ADH水平低于治疗后（P<0.05），治疗前上午10点的ADH水平与治疗后无显著差异（P>0.05）。治疗后上午10点和晚上11点，研究组和对照组的血清TNF-α和IL-6水平均下降（P<0.05）。治疗前研究组和对照组的血清TNF-α和IL-6水平无显著差异（P>0.05）。与单纯针刺相比，中药止遗汤联合针刺治疗小儿遗尿症疗效更确切，能有效改善遗尿症状。
