Gómez Caballero Nazaret, Almenara Susana, Tévar Terol Antonia, Horga de la Parte José Francisco
Department of Primary Care, Hospital General Universitari d'Alacant, Alicante, Spain.
Department of Clinical Pharmacology, Hospital General Universitari d'Alacant, Alicante, Spain.
BMJ Case Rep. 2019 Mar 8;12(3):e227398. doi: 10.1136/bcr-2018-227398.
We present a case of a possible amoxicillin-induced anaphylaxis in a sensitive woman triggered by an instance of oral sexual contact with a man who was taking amoxicillin-clavulanic acid treatment.To our knowledge, this is the first case reported of a suspicion of amoxicillin-induced anaphylaxis in a woman after a sexual contact with a man who was taking the drug, we hypothesised an oral drug transfer through semen.Studies about amoxicillin concentrations achieved in semen after a drug intake are scarce. There are few cases reported of hypersensitivity reactions induced by drugs transported in semen but we have found some concern in sensitive patients about the possibility of transference of allergens via sexual intercourse. As clinicians, we consider that it is important to be aware of the existence of this possibility both in the diagnosis and in the prevention of anaphylactic reactions.
我们报告了一例可能由阿莫西林引起的过敏反应病例，该反应发生在一名敏感女性身上，诱因是与一名正在接受阿莫西林 - 克拉维酸治疗的男性进行口交。据我们所知，这是首例报告的怀疑女性在与服用该药物的男性发生性接触后出现阿莫西林诱导的过敏反应的病例，我们推测药物通过精液进行了口服转移。关于服药后精液中阿莫西林浓度的研究很少。虽然仅有少数精液中携带药物引发过敏反应的病例报告，但我们发现敏感患者对通过性交转移过敏原的可能性存在一些担忧。作为临床医生，我们认为在诊断和预防过敏反应时，意识到这种可能性的存在很重要。
