Fang Yuan, Zhang Yufang, Zhou Jianda, Cao Ke
The Third Xiangya Hospital of Central South University, No.138.Tongzipo Road, 410013, Changsha, Hunan, People's Republic of China.
Anyang Tumor Hospital, No. 1 Huanbin North Road, 455000, Anyang, Henan, People's Republic of China.
Cell Tissue Bank. 2019 Jun;20(2):153-161. doi: 10.1007/s10561-019-09761-y. Epub 2019 Mar 9.
The well-characterized curative effect of transplanted mesenchymal stem cells has been mainly attributed to their homing and subsequent differentiation for the repair and regeneration of damaged tissue. Adipose-derived mesenchymal stem cells (ADMSCs) are not only multipotent and plastic, but also abundant as they can be easily harvested with minimally invasive surgical techniques. This makes ADMSCs conducive for clinical applications. Recently, the secretory function of ADMSCs has been regarded as the primary mediator of MSC-based therapy. Exosomes are one kind of small cell extracellular membrane vesicles, which are primarily used to deliver cell-specific proteins, as well as nucleic acids secreted by various cell types. This review will introduce and characterize exosomes-derived ADMSCs (ADMSCs-Exo) and look at new therapies and prospective, including the limitations and outlook for therapeutic strategy. We will describe the latest research progress on myocardial repair, neuroprotection and neurotrophic effects, hepatic repair, renal repair, cutaneous repair, regeneration and other aspects using these cells.
移植间充质干细胞具有明确的治疗效果，这主要归因于它们的归巢能力以及随后为修复和再生受损组织而进行的分化。脂肪来源的间充质干细胞（ADMSCs）不仅具有多能性和可塑性，而且数量丰富，因为它们可以通过微创外科技术轻松获取。这使得ADMSCs有利于临床应用。最近，ADMSCs的分泌功能被认为是基于间充质干细胞治疗的主要介导因素。外泌体是一种小的细胞外膜囊泡，主要用于递送细胞特异性蛋白质以及各种细胞类型分泌的核酸。本综述将介绍并描述源自ADMSCs的外泌体（ADMSCs-Exo），并探讨新的治疗方法和前景，包括治疗策略的局限性和展望。我们将描述使用这些细胞在心肌修复、神经保护和神经营养作用、肝脏修复、肾脏修复、皮肤修复、再生等方面的最新研究进展。
