用于生物标志物组合分析的PanelomiX技术

PanelomiX for the Combination of Biomarkers.

作者信息

Robin Xavier

机构信息

Swiss Institute of Bioinformatics, University of Basel, Biozentrum, Klingelbergstrasse, Basel, Switzerland.

出版信息

Methods Mol Biol. 2019;1959:261-273. doi: 10.1007/978-1-4939-9164-8_17.

DOI:10.1007/978-1-4939-9164-8_17

PMID:30852828

Abstract

Proteomics has allowed the discovery and validation of a massive number of biomarkers. However most of them suffer from insufficient specificity and sensitivity and therefore didn't translate to clinical practice. Combining biomarkers with different properties into panels can be an efficient way to bypass these limitations and facilitate the translation of biomarkers into clinical practice.

摘要

蛋白质组学已助力发现并验证了大量生物标志物。然而，其中大多数生物标志物的特异性和敏感性不足，因此未能转化为临床应用。将具有不同特性的生物标志物组合成生物标志物组，可能是克服这些局限性并促进生物标志物转化为临床应用的有效方法。