Acute and chronic effects of thyrotropin-releasing hormone (TRH) on stabilogram in spinocerebellar degenerations.

A single blind cross over trial was conducted of thyrotropin-releasing hormone treatment in 7 patients with spinocerebellar degenerations. Patients received daily 2 mg of thyrotropin releasing hormone intramuscularly during the 2 week treatment period. Acute beneficial effect on stabilogram was demonstrated, but significant therapeutic efficacy in the chronic treatment failed to be demonstrated, though a trend of effectiveness was observed.