Kimura I, Ohtomo H, Kogure K
Tohoku J Exp Med. 1983 Apr;139(4):331-7. doi: 10.1620/tjem.139.331.
Fine aiming task was studied quantitatively in 20 patients with spinocerebellar degeneration (SCD) and 8 normal control subjects, utilizing a manual control system with random-step input signal. The transfer function of the system was an integral function and ability to perform a 'differentiating action' compensating for this integral function was analyzed. This 'differentiating action' was defective in all patients with SCD and was normal in all control subjects. A display of the dynamic characteristics of subjects on the plane defined by principal component analysis of the parameters showed definite delineation of the characteristics of patients from those of the controls. The intramuscular injection of thyrotropin-releasing hormone (TRH) resulted in an increase in amplitude of manipulation, a shortening of reaction time and consequently an improvement in motor disabilities in 65% of 20 patients with SCD.
利用带有随机步长输入信号的手动控制系统，对20例脊髓小脑变性（SCD）患者和8名正常对照者进行了精细瞄准任务的定量研究。该系统的传递函数为积分函数，并分析了执行补偿此积分函数的“微分作用”的能力。所有SCD患者的这种“微分作用”均存在缺陷，而所有对照者的该作用均正常。在由参数的主成分分析定义的平面上显示受试者的动态特征，明确区分了患者与对照者的特征。对20例SCD患者中的65%进行肌肉注射促甲状腺激素释放激素（TRH）后，操作幅度增加，反应时间缩短，从而运动障碍得到改善。
