Gheorghita Dorottya, Eördegh Gabriella, Nagy Ferenc, Antal Márk
Konzerváló és Esztétikai Fogászati Tanszék, Szegedi Tudományegyetem, Fogorvostudományi Kar Szeged, Tisza Lajos körút 64-66., 6720.
II. Belgyógyászati Klinika és Kardiológiai Központ, Invazív Kardiológiai Részleg, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged.
Orv Hetil. 2019 Mar;160(11):419-425. doi: 10.1556/650.2019.31301.
Cardiovascular disease is recognized as the leading cause of death and disability in the world. The majority of these deaths can be attributed to atherosclerotic disease and thromboembolic events leading to ischemic heart disease and stroke. The role of inflammation is well recognized in the pathogenesis of atherosclerosis and atherothrombosis. Increasing number of studies support the hypothesis that periodontal disease, specifically periodontitis, is a potential risk factor for atherosclerosis and thus cardiovascular disease. Chronic infections of periodontal pockets act as reservoirs for pathogenic microorganisms, their toxins and degradation products, raising the overall systemic inflammatory burden. Entering the circulation and atherosclerotic lesions themselves, they lead to further local and systemic inflammatory response, in all contributing to atherosclerosis progression, potentially increasing cardiovascular risk. Along these lines, good oral health in general and the periodontal treatment in more severe cases may play a role in cardiovascular risk reduction, primary and secondary prevention. The present review summarizes the possible pathophysiological mechanisms linking periodontal and cardiovascular pathology, lists clinical evidence between periodontitis and specific forms of cardiovascular disease and looks forward at the potential role of periodontal treatment in cardiovascular disease prevention and treatment. Orv Hetil. 2019; 160(11): 419-425.
心血管疾病被公认为全球死亡和残疾的主要原因。这些死亡中的大多数可归因于动脉粥样硬化疾病和导致缺血性心脏病和中风的血栓栓塞事件。炎症在动脉粥样硬化和动脉粥样硬化血栓形成的发病机制中的作用已得到充分认识。越来越多的研究支持这样一种假说，即牙周疾病，特别是牙周炎，是动脉粥样硬化进而心血管疾病的潜在危险因素。牙周袋的慢性感染充当致病微生物、其毒素和降解产物的储存库，增加了整体全身炎症负担。它们进入循环系统和动脉粥样硬化病变本身，导致进一步的局部和全身炎症反应，所有这些都促成动脉粥样硬化的进展，可能增加心血管风险。因此，总体而言良好的口腔健康以及在更严重情况下的牙周治疗可能在降低心血管风险、一级预防和二级预防中发挥作用。本综述总结了将牙周病与心血管病理联系起来的可能病理生理机制，列出了牙周炎与特定形式心血管疾病之间的临床证据，并展望了牙周治疗在心血管疾病预防和治疗中的潜在作用。《匈牙利医学周报》。2019年；160(11):419 - 425。
