1 Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, Santa Catarina, Brazil.
2 São José Hospital Research Centre, Criciúma, Santa Catarina, Brazil.
J Geriatr Psychiatry Neurol. 2019 May;32(3):119-136. doi: 10.1177/0891988719834346. Epub 2019 Mar 10.
Delirium is a serious and common disorder that affects up to 80% of acutely ill patients, mainly the aged. In recent years, several studies pointed out possible biomarkers that could be used alone or in combination with other resources in the diagnosis and follow-up of critically ill patients who develop delirium. In this context, a systematic review was conducted to determine the predictive value of several biomarkers in acutely (critically and noncritically) ill adult patients with delirium. Studies that used the confusion assessment method (CAM) and CAM-intensive care unit as the diagnostic method were considered. The most recent search was performed in November 2017. There was no language restriction. Initially, 626 articles were screened and 39 were included in the study. A comprehensive evaluation of the abstracts resulted in the exclusion of 202 studies, leaving 39 articles as potentially relevant. Inflammatory markers, S100β and cortisol, could predict delirium occurrence in a specific subgroup population of critically ill patients.
谵妄是一种严重且常见的疾病，影响多达 80%的急性病患者，主要是老年人。近年来，多项研究指出了一些可能的生物标志物，这些标志物可单独或与其他资源结合用于诊断和随访发生谵妄的危重病患者。在这种情况下，进行了一项系统评价，以确定几种生物标志物在急性（危重症和非危重症）成年谵妄患者中的预测价值。研究采用了意识模糊评估法（CAM）和重症监护病房意识模糊评估法（CAM-ICU）作为诊断方法。最近的一次搜索是在 2017 年 11 月进行的，没有语言限制。最初筛选了 626 篇文章，有 39 篇纳入研究。对摘要进行综合评估后，排除了 202 项研究，留下 39 篇文章作为潜在相关研究。炎症标志物、S100β 和皮质醇可预测特定危重病患者亚群中谵妄的发生。
