Department of Gastroenterology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Int J Biol Markers. 2019 Jun;34(2):117-122. doi: 10.1177/1724600818812471. Epub 2019 Mar 11.
The correlation between patatin-like phospholipase domain-containing protein 3 () rs738409 polymorphism and hepatocellular carcinoma was investigated by several pilot studies, but the results of these studies were controversial. Therefore, we performed this study to better assess the relationship between rs738409 polymorphism and the likelihood of hepatocellular carcinoma.
Eligible studies were searched in PubMed, Medline, EMBASE, and Web of Science. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the relationship between rs738409 polymorphism and hepatocellular carcinoma.
A total of 17 studies with 10,330 participants were analyzed. A significant association with the likelihood of hepatocellular carcinoma was detected for the rs738409 polymorphism in dominant ( = 0.0001; OR 0.66; 95% CI 0.53, 0.82), recessive ( < 0.0001; OR 2.32; 95% CI 1.76, 3.06) and allele ( < 0.0001; OR 0.64; 95% CI 0.53, 0.77) comparisons. Further subgroup analyses revealed that the rs738409 polymorphism was significantly associated with the likelihood of hepatocellular carcinoma in Caucasians (dominant model: < 0.0001, OR 0.57, 95% CI 0.45, 0.71; recessive model: < 0.0001, OR 2.74, 95% CI 2.02, 3.71; allele model: < 0.0001, OR 0.56, 95% CI 0.46, 0.67). However, no positive results were detected in Asians.
Our findings indicated that the rs738409 polymorphism may serve as a potential biological marker of hepatocellular carcinoma in Caucasians.
几项初步研究探讨了载脂蛋白样磷脂酶域蛋白 3() rs738409 多态性与肝细胞癌之间的相关性，但这些研究的结果存在争议。因此，我们进行了这项研究，以更好地评估 rs738409 多态性与肝细胞癌发生的可能性之间的关系。
在 PubMed、Medline、EMBASE 和 Web of Science 中检索符合条件的研究。使用比值比（ORs）和 95%置信区间（CIs）来评估 rs738409 多态性与肝细胞癌之间的关系。
共纳入 17 项研究，包含 10330 名参与者。结果显示，在显性（=0.0001；OR 0.66；95%CI 0.53，0.82）、隐性（<0.0001；OR 2.32；95%CI 1.76，3.06）和等位基因（<0.0001；OR 0.64；95%CI 0.53，0.77）比较中，rs738409 多态性与肝细胞癌的发生均存在显著相关性。进一步的亚组分析显示，rs738409 多态性与白人肝细胞癌的发生显著相关（显性模型：<0.0001，OR 0.57，95%CI 0.45，0.71；隐性模型：<0.0001，OR 2.74，95%CI 2.02，3.71；等位基因模型：<0.0001，OR 0.56，95%CI 0.46，0.67）。然而，在亚洲人中未检测到阳性结果。
我们的研究结果表明，rs738409 多态性可能是白人肝细胞癌的潜在生物学标志物。
