Cobbold S, Waldmann H
Transplantation. 1986 May;41(5):634-9. doi: 10.1097/00007890-198605000-00016.
The L3/T4+ and Lyt-2+ T-cell subsets can be depleted from mice, using selected monoclonal antibodies in vivo, at different times during rejection of, or priming to, allogeneic skin grafts. Although L3/T4+ cells are sufficient to reject skin grafts in naive Lyt-2-depleted mice, we show that Lyt-2+ cells can become involved, after an initial delay, in intact mice. Furthermore, these Lyt-2+ cells are primed to dominate the accelerated rejection of a normal secondary response. Mice depleted of L3/T4+ cells cannot be primed in this way, suggesting that priming of Lyt-2+ cells is dependent on help from L3/T4+ cells. However, in mice depleted of Lyt-2+ cells, priming for rapid rejection can be achieved, presumably via the L3/T4+ population. This suggests that the rejection of skin allografts in a given situation reflects different contributions of multiple effector mechanisms.
在同种异体皮肤移植排斥反应或致敏过程中的不同时间，利用特定的单克隆抗体在体内可使小鼠的L3/T4⁺和Lyt-2⁺ T细胞亚群减少。虽然L3/T4⁺细胞足以在初始Lyt-2缺失的小鼠中排斥皮肤移植，但我们发现，在完整小鼠中，Lyt-2⁺细胞经过初始延迟后也会参与其中。此外，这些Lyt-2⁺细胞被致敏以主导正常二次反应的加速排斥。L3/T4⁺细胞缺失的小鼠不能以这种方式被致敏，这表明Lyt-2⁺细胞的致敏依赖于L3/T4⁺细胞的辅助。然而，在Lyt-2⁺细胞缺失的小鼠中，大概通过L3/T4⁺群体可以实现快速排斥的致敏。这表明在特定情况下皮肤同种异体移植的排斥反映了多种效应机制的不同贡献。
