Müller I, Cobbold S P, Waldmann H, Kaufmann S H
Infect Immun. 1987 Sep;55(9):2037-41. doi: 10.1128/iai.55.9.2037-2041.1987.
The resistance of mice against Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells was studied. Thymectomized mice were treated with rat monoclonal antibodies against the L3T4 or Lyt-2 molecule to selectively eliminate the respective T-cell subset. In both L3T4+ and Lyt-2+ T-cell-depleted mice, resistance against subsequent infection with M. tuberculosis was markedly impaired compared with that in untreated controls, with L3T4+ T-cell-depleted mice showing more pronounced effects. Simultaneous depletion of L3T4+ and Lyt-2+ T cells did not further exacerbate infection. These findings suggest that both L3T4+ and Lyt-2+ T cells are involved in the acquisition of resistance against tuberculosis.
研究了在体内选择性清除L3T4 +和Lyt-2 + T细胞后小鼠对结核分枝杆菌感染的抵抗力。对胸腺切除的小鼠用抗L3T4或Lyt-2分子的大鼠单克隆抗体进行处理,以选择性地消除各自的T细胞亚群。与未处理的对照相比,在L3T4 +和Lyt-2 + T细胞耗竭的小鼠中,对随后结核分枝杆菌感染的抵抗力均明显受损,其中L3T4 + T细胞耗竭的小鼠表现出更明显的效果。同时清除L3T4 +和Lyt-2 + T细胞并未进一步加重感染。这些发现表明,L3T4 +和Lyt-2 + T细胞均参与了对结核病抵抗力的获得。