PhD Candidate, Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Associate Professor, Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 May;127(5):393-398. doi: 10.1016/j.oooo.2019.01.073. Epub 2019 Feb 6.
The aim of this study was to describe 2 patients with piroxicam-associated fixed drug eruption on the tongue and to review the literature.
Two females presented with recurrent ulcers after taking piroxicam for dysmenorrhea and pelvic pain. The English language literature was reviewed for cases of piroxicam-induced fixed drug eruptions, with a report on the site of occurrence.
The ulcers reappeared in the identical lingual site after piroxicam intake; 3 times in patient #1 and 2 times in patient #2. Extraoral lesions were not observed. Following discontinuation of piroxicam, no relapse was reported. The literature review found 25 patients with piroxicam-associated fixed drug eruption. The oral mucosa/lips were affected in 8 patients who also had cutaneous/genital lesions. Solitary tongue involvement was not reported in any of them. Cross-sensitivity among different drugs of the same class is not unusual.
Fixed drug reactions to piroxicam are rare, although nonsteroidal antiinflammatory drugs are among the most common causes of fixed drug eruptions. Of these rare fixed drug reactions to piroxicam, cutaneous lesions are reported much more often compared with oral mucosal lesions. Discontinuation of the causative drug is essential to promote healing and to avoid recurrences. Patients with history of piroxicam-induced fixed drug eruption should also avoid other oxicams because of potential cross-sensitivity.
本研究旨在描述 2 例吡罗昔康相关性固定性药疹患者，并复习相关文献。
2 例女性因痛经和盆腔痛服用吡罗昔康后出现复发性溃疡。检索了英语文献中吡罗昔康引起的固定性药疹病例，并报告了发生部位。
患者 #1 共 3 次、患者 #2 共 2 次在服用吡罗昔康后于同一舌部位置出现溃疡。未观察到口腔外病变。停用吡罗昔康后，未再复发。文献复习发现 25 例吡罗昔康相关性固定性药疹患者。8 例口腔黏膜/唇受累的患者同时有皮肤/生殖器病变。其中无一例报告单纯舌部受累。同一类药物之间的交叉过敏并不罕见。
吡罗昔康引起的固定性药疹虽然非甾体抗炎药是固定性药疹最常见的原因之一，但较为罕见。这些罕见的吡罗昔康相关性固定性药疹中，皮肤病变比口腔黏膜病变报告更为常见。停用致病药物对于促进愈合和避免复发至关重要。有吡罗昔康诱导的固定性药疹病史的患者也应避免使用其他昔布类药物，因为存在潜在的交叉过敏。
