Ordoqui E, De Barrio M, Rodríguez V M, Herrero T, Gil P J, Baeza M L
Sección de Alergología, Hospital General Universitario Gregoria Marañón, Madrid, Spain.
Allergy. 1995 Sep;50(9):741-4. doi: 10.1111/j.1398-9995.1995.tb01216.x.
Fixed drug eruption (FDE) caused by oxicams is very rare. There are few reports of FDE induced by piroxicam, and this explains why cross-sensitivity among oxicams (piroxicam, tenoxicam, and droxicam) has been studied in only one patient. The patch test on residual lesions has lately been used by some authors in FDE diagnosis with variable results. We describe two cases of piroxicam-caused FDE and demonstrate cross-sensitivity among piroxicam, tenoxicam, and droxicam in both of them. One patient had residual lesions and the patch test was useful for diagnosis and cross-sensitization studies. The second patient had no residual lesions, and the patch test was negative on normal but previously affected skin; therefore, the study was performed by single-blind controlled oral challenge.
由昔康类药物引起的固定性药疹（FDE）非常罕见。关于吡罗昔康诱发FDE的报道很少，这也解释了为何仅在一名患者中研究了昔康类药物（吡罗昔康、替诺昔康和droxicam）之间的交叉敏感性。近来一些作者将对残留皮损的斑贴试验用于FDE诊断，结果不一。我们描述了两例由吡罗昔康引起的FDE病例，并在这两例中证实了吡罗昔康、替诺昔康和droxicam之间的交叉敏感性。一名患者有残留皮损，斑贴试验对诊断和交叉致敏研究有用。第二名患者没有残留皮损，对正常但先前受累皮肤的斑贴试验为阴性；因此，通过单盲对照口服激发试验进行研究。
