Department of Radiology, Mayo Clinic, Rochester MN, USA.
Department of Health Science Research, Mayo Clinic, Rochester MN, USA.
Alzheimers Dement. 2019 May;15(5):675-685. doi: 10.1016/j.jalz.2018.12.016. Epub 2019 Mar 8.
Little is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer's disease (AD).
Regional tau and β-amyloid positron emission tomography standard uptake value ratios and gray matter volumes were calculated in a cohort of 42 participants with atypical AD. The relationship between regional metrics and age was modeled using a Bayesian hierarchical linear model.
Age was strongly associated with tau uptake across all cortical regions, particularly parietal, with greater uptake in younger participants. Younger age was associated with smaller parietal and lateral temporal volumes. Regional β-amyloid differed little by age. Age showed a stronger association with tau than volume and β-amyloid in all cortical regions. Age was not associated with cognitive performance.
Age is an important determinant of severity of cortical tau uptake in atypical AD, with young participants more likely to show widespread and severe cortical tau uptake.
关于年龄对阿尔茨海默病（AD）非典型变异体中神经退行性变和蛋白质沉积的作用知之甚少。
在一组 42 名非典型 AD 患者中计算了区域性 tau 和 β-淀粉样蛋白正电子发射断层扫描标准摄取比值和灰质体积。使用贝叶斯分层线性模型对区域指标与年龄之间的关系进行建模。
年龄与所有皮质区域的 tau 摄取均呈强相关，尤其是顶叶，年轻参与者的摄取量更大。年龄较小与顶叶和外侧颞叶体积较小有关。β-淀粉样蛋白的区域差异很小。在所有皮质区域中，年龄与 tau 的相关性均强于体积和 β-淀粉样蛋白。年龄与认知表现无关。
年龄是非典型 AD 中皮质 tau 摄取严重程度的重要决定因素，年轻参与者更有可能表现出广泛而严重的皮质 tau 摄取。
