Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.
J Nucl Med. 2018 Feb;59(2):299-306. doi: 10.2967/jnumed.117.194282. Epub 2017 Jul 26.
Nonamnestic Alzheimer disease (AD) variants, including posterior cortical atrophy and the logopenic variant of primary progressive aphasia, differ from amnestic AD in distributions of tau aggregates and neurodegeneration. We evaluated whether F-flortaucipir (also called F-AV-1451) PET, targeting tau aggregates, detects these differences, and we compared the results with MRI measures of gray matter (GM) atrophy. Five subjects with posterior cortical atrophy, 4 subjects with the logopenic variant of primary progressive aphasia, 6 age-matched patients with AD, and 6 control subjects underwent F-flortaucipir PET and MRI. SUV ratios and GM volumes were compared using regional and voxel-based methods. The subgroups showed the expected F-flortaucipir-binding patterns. Group effect sizes were generally stronger with F-flortaucipir PET than with MRI volumes. There were moderate-to-high correlations between regional GM atrophy and F-flortaucipir uptake. F-flortaucipir binding and GM atrophy correlated similarly to cognitive test performance. F-flortaucipir binding corresponds to the expected neurodegeneration patterns in nonamnestic AD, with potential for earlier detection of pathology than is possible with MRI atrophy measures.
非遗忘型阿尔茨海默病（AD）变体，包括后部皮质萎缩和原发性进行性失语的失语法变体，在tau 聚集物和神经退行性变的分布上与遗忘型 AD 不同。我们评估了靶向 tau 聚集物的 F-氟替卡培（也称为 F-AV-1451）PET 是否能检测到这些差异，并将结果与灰质（GM）萎缩的 MRI 测量值进行了比较。5 名后部皮质萎缩患者、4 名失语法原发性进行性失语患者、6 名年龄匹配的 AD 患者和 6 名对照受试者接受了 F-氟替卡培 PET 和 MRI 检查。使用基于区域和体素的方法比较了 SUV 比值和 GM 体积。亚组显示了预期的 F-氟替卡培结合模式。与 MRI 体积相比，F-氟替卡培 PET 的组效应大小通常更强。区域 GM 萎缩与 F-氟替卡培摄取之间存在中度至高相关性。F-氟替卡培结合与 GM 萎缩与认知测试表现的相关性相似。F-氟替卡培结合与非遗忘型 AD 中预期的神经退行性变模式相对应，与 MRI 萎缩测量相比，有可能更早地检测到病理。
