Department of Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
Prog Neurobiol. 2019 May;176:54-72. doi: 10.1016/j.pneurobio.2019.03.001. Epub 2019 Mar 7.
Several lines of evidence have suggested that mitochondrial dysfunction plays a key role in neurodegeneration. The mitochondrial function is a potential target for steroid hormones, which could exert protective activities in the brain and other tissues. The decrease of some sex steroids with aging has been associated with deleterious effects on brain function and progression to neurodegenerative diseases. Recent in vitro and in vivo evidence provides the basis for this review on the interplay of sex steroids and mitochondrial defects in preventing or improving pathological events in the central nervous system (CNS). In this article, the role of mitochondria under normal and pathological states will be discussed. In addition, we will review studies conducted on steroidal compounds, which have neuroprotective effects targeting mitochondria. It has been shown that these compounds could exert both direct and indirect effects on mitochondria that promote or preserve mitochondrial function under pathological circumstances, such as acute brain injury and chronic neurodegeneration.
有几条证据表明线粒体功能障碍在神经退行性变中起着关键作用。线粒体功能是甾体激素的一个潜在靶点，甾体激素可以在大脑和其他组织中发挥保护作用。随着年龄的增长，一些性激素的减少与大脑功能的有害影响以及向神经退行性疾病的发展有关。最近的体外和体内证据为本文提供了基础，本文综述了性激素和线粒体缺陷在预防或改善中枢神经系统（CNS）病理事件中的相互作用。在本文中，将讨论正常和病理状态下线粒体的作用。此外，我们还将回顾针对线粒体具有神经保护作用的甾体化合物的研究。已经表明，这些化合物可以在病理情况下（如急性脑损伤和慢性神经退行性变）对线粒体产生直接和间接的影响，从而促进或维持线粒体功能。
