Kim Tammy D, Hong Gahae, Kim Jungyoon, Yoon Sujung
Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul 03760, Korea.
Ewha Brain Institute, Ewha Womans University, Seoul 03760, Korea.
Exp Neurobiol. 2019 Feb;28(1):1-16. doi: 10.5607/en.2019.28.1.1. Epub 2019 Feb 28.
Cognitive enhancement refers to the improvement of cognitive function related to deficits that occurred as part of a certain illness. However, the term cognitive enhancement does not yet have a definitive meaning, and its connotations often vary depending on the research of interest. Recently, research interests are growing towards enhancing human cognition beyond what has traditionally been considered necessary using various brain devices. The phenomenon of exceeding the cognitive abilities of individuals who are already functional has also introduced new terminologies as means to classify between cognitive enhancing procedures that are part of treatment versus simply supplementary. Of the many devices used to attain cognitive enhancement, transcranial magnetic stimulation (TMS) is a unique neurostimulatory device that has demonstrated significant improvements in various cognitive domains including memory and cognitive processing skills. While many studies have supported the safety and efficacy of TMS in treatment, there has yet to be an optimization in parameter for TMS that is catered to a certain target group. The current paper aims to review with perspective the many studies that have used TMS for the purpose of cognitive enhancement and provide further insight on the development of an optimal stimulation parameter. The paper reviews 41 peer-reviewed articles that used TMS for cognitive enhancement, summarizes the findings that were apparent for each distinct parameter, and discusses future directions regarding TMS as an elective tool for healthy individuals while considering some of the ethical perspectives that may be warranted.
认知增强是指改善与特定疾病所导致的认知功能缺陷相关的认知功能。然而,“认知增强”一词尚无明确的定义,其内涵往往因研究兴趣而异。最近,人们越来越关注利用各种脑部设备来增强人类认知,使其超越传统上认为必要的水平。超越已有正常认知能力个体的现象也引入了新的术语,用于区分作为治疗一部分的认知增强程序与单纯的补充程序。在用于实现认知增强的众多设备中,经颅磁刺激(TMS)是一种独特的神经刺激设备,已在包括记忆和认知处理技能在内的各种认知领域显示出显著改善。虽然许多研究支持TMS治疗的安全性和有效性,但尚未针对特定目标群体对TMS参数进行优化。本文旨在从不同角度回顾众多使用TMS进行认知增强的研究,并对开发最佳刺激参数提供进一步的见解。本文回顾了41篇使用TMS进行认知增强的同行评审文章,总结了每个不同参数的明显研究结果,并在考虑一些可能需要的伦理观点的同时,讨论了将TMS作为健康个体的选择性工具的未来方向。
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