G12V突变是中国胃癌患者的不良预后因素。
G12V Mutation is an Adverse Prognostic Factor of Chinese Gastric Cancer Patients.
作者信息
Fu Xin-Hui, Chen Zhi-Ting, Wang Wen-Hui, Fan Xin-Juan, Huang Yan, Wu Xiao-Bin, Huang Jing-Lin, Wang Jing-Xuan, Lin Han-Jie, Tan Xiao-Li, Wang Lei, Wang Jian-Ping
机构信息
Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
出版信息
J Cancer. 2019 Jan 29;10(4):821-828. doi: 10.7150/jca.27899. eCollection 2019.
This study aims to investigate the molecular characteristics of Chinese gastric cancer patients. In our study, the , , and mutation status of 485 GC patients were analyzed by Sanger sequencing. Kaplan-Meier analysis was used to plot survival curves according to different genotypes. The results show that the frequency of , and mutations were 4.1%, 1.2% and 3.5%, respectively. mutations were significantly concentrated in stage III and IV gastric cancer (=0.009). G12V mutation carriers have much shorter OS than other mutation carriers and wild-type group patients (=0.013). In conclusion, only the G12V mutation has an adverse effect on patient survival.
本研究旨在调查中国胃癌患者的分子特征。在我们的研究中，通过桑格测序分析了485例胃癌患者的 、 和 突变状态。采用Kaplan-Meier分析根据不同基因型绘制生存曲线。结果显示， 、 和 突变的频率分别为4.1%、1.2%和3.5%。 突变显著集中在III期和IV期胃癌（=0.009）。G12V突变携带者的总生存期比其他突变携带者和野生型组患者短得多（=0.013）。总之，只有 G12V突变对患者生存有不利影响。
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