Getz Godfrey S, Reardon Catherine A
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
Ben May Institute for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.
J Immunol Sci. 2018;2(3):69-76. doi: 10.29245/2578-3009/2018/3.1144. Epub 2018 Jun 27.
Atherosclerosis is the underlying basis for most cardiovascular diseases. It is a chronic inflammation affecting the arterial intima and is promoted by hypercholesterolemia. Cells of both the innate and adaptive immune systems contribute to this inflammation with macrophages and T cells being the most abundant immune cells in the atherosclerotic plaques. In this review, we discuss the studies that examined the role of T cells and T cell subsets in and murine models of atherosclerosis. While there is a general consensus that Th1 cells are pro-atherogenic and regulatory T cells are atheroprotective, the role of other subsets is more ambiguous. In addition, the results in the two models of atherosclerosis do not always yield similar results. Additional studies in the two murine models using cell specific gene manipulations are needed.
动脉粥样硬化是大多数心血管疾病的潜在基础。它是一种影响动脉内膜的慢性炎症，由高胆固醇血症引发。先天免疫系统和适应性免疫系统的细胞都参与了这种炎症反应，巨噬细胞和T细胞是动脉粥样硬化斑块中最丰富的免疫细胞。在本综述中，我们讨论了研究T细胞及其亚群在动脉粥样硬化小鼠模型和 模型中作用的相关研究。虽然普遍认为Th1细胞具有促动脉粥样硬化作用，而调节性T细胞具有抗动脉粥样硬化保护作用，但其他亚群的作用则更为模糊。此外，两种动脉粥样硬化模型的研究结果并不总是一致。需要在这两种小鼠模型中进行更多使用细胞特异性基因操作的研究。
