Numaguchi Y, Weems A M, Mizushima A, Keating J, Rege A B, Mather F J, Rice J C
AJNR Am J Neuroradiol. 1986 May-Jun;7(3):498-501.
Moderately severe side effects, such as prolonged headache, nausea, vomiting, or psychoneurologic symptoms, were noted in 27 (32%) of 84 patients in whom the contrast medium was not removed. Conversely, among 73 patients from whom 20-25 ml of cerebrospinal fluid with the contrast medium was removed, only 10 (14%) experienced adverse effects, a statistically significant reduction. Although new contrast agents, such as iohexol and iopamidol, are reportedly less toxic than metrizamide, the contrast-removal technique described here may be indicated when large amounts of any contrast medium are used.
在84例未去除造影剂的患者中，有27例（32%）出现了中度严重的副作用，如持续性头痛、恶心、呕吐或精神神经症状。相反，在73例去除了20 - 25毫升含造影剂脑脊液的患者中，只有10例（14%）出现了不良反应，这一比例有统计学意义的降低。尽管据报道，新型造影剂如碘海醇和碘帕醇的毒性低于甲泛葡胺，但当使用大量任何造影剂时，此处描述的造影剂去除技术可能是适用的。
