Latchaw R E, Hirsch W L, Horton J A, Bissonette D, Shaw D D
AJNR Am J Neuroradiol. 1985 Nov-Dec;6(6):931-3.
A double-blind study was conducted in 60 patients undergoing either cervical or more complete myelography via C1-C2 puncture. Patients received either iohexol or metrizamide at a 300 mg l/ml concentration. The contrast media were equally efficacious in the production of high-quality radiographs and CT scans. However, the incidence of adverse reactions differed markedly. Of patients receiving metrizamide, 68% had some type of adverse reaction, whereas only 26% receiving iohexol had symptoms. The incidence of headache (metrizamide, 34%; iohexol, 26%) was not statistically different, but the quality of the headache differed: half of the metrizamide headaches were moderate or severe, whereas all iohexol headaches were mild. Nausea (31%) and vomiting (28%) were common with metrizamide but unusual (3% nausea) with iohexol. Of the metrizamide patients, 21% had overt psychologic changes that did not occur in the iohexol group.
对60例经C1 - C2穿刺进行颈椎或更全面脊髓造影的患者进行了一项双盲研究。患者接受浓度为300mg碘/ml的碘海醇或甲泛葡胺。两种造影剂在产生高质量的X光片和CT扫描方面同样有效。然而，不良反应的发生率差异显著。接受甲泛葡胺的患者中，68%出现了某种类型的不良反应，而接受碘海醇的患者中只有26%出现症状。头痛的发生率（甲泛葡胺为34%，碘海醇为26%）无统计学差异，但头痛的程度不同：甲泛葡胺引起的头痛有一半为中度或重度，而碘海醇引起的头痛均为轻度。恶心（31%）和呕吐（28%）在使用甲泛葡胺时很常见，但在使用碘海醇时不常见（恶心发生率为3%）。在使用甲泛葡胺的患者中，21%出现了明显的心理变化，而碘海醇组未出现此类情况。
