Hashemi Nasseh, Valk Tim, Houlind Kim, Ejskjaer Niels
1 School of Medicine and Health, Aalborg University, Aalborg, Denmark.
2 Steno Diabetes Center North Jutland, Aalborg, Denmark.
J Diabetes Sci Technol. 2019 Sep;13(5):941-948. doi: 10.1177/1932296819832876. Epub 2019 Mar 10.
Deviations in glucose control in critical care have been shown to increase mortality and morbidity. However, optimal glucose control through present technologies has shown to be a challenge. The insulin balanced infusion system (IBIS) is a new and emerging technology.
The closed loop system was tested in a stress trial to evaluate glucose stability in response to various conditions in nonrandomized people with type 1 diabetes mellitus (n=12). The prototype used in this trial was based on intermittent capillary measurements.
Induced stresses in the study using unpredicted stimuli of intravenous or oral glucose and intravenous insulin boluses, was contained with glucose remaining in target 43.8% of the time. Mean increase in glucose concentration after glucose load was 17.4 mg/dl; after insulin bolus, no hypoglycemia (blood glucose less than 70 mg/dl) occurred.
The use of IBIS proved safe and feasible under a wide range of conditions. The sensing and stress response of the IBIS demonstrated noticeable features.
重症监护中血糖控制的偏差已被证明会增加死亡率和发病率。然而，通过现有技术实现最佳血糖控制已被证明是一项挑战。胰岛素平衡输注系统（IBIS）是一种新兴技术。
在一项应激试验中对闭环系统进行了测试，以评估12例非随机1型糖尿病患者在各种条件下的血糖稳定性。本试验中使用的原型基于间歇性毛细血管测量。
在研究中，通过静脉或口服葡萄糖以及静脉注射胰岛素推注的不可预测刺激诱导应激，血糖保持在目标范围内的时间占43.8%。葡萄糖负荷后血糖浓度的平均升高为17.4mg/dl；注射胰岛素推注后，未发生低血糖（血糖低于70mg/dl）。
在广泛的条件下，IBIS的使用被证明是安全可行的。IBIS的传感和应激反应表现出显著特征。
