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本文引用的文献

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Acquired mechanisms of immune escape in cancer following immunotherapy.免疫治疗后癌症中获得性免疫逃逸机制。
Genome Med. 2018 Nov 22;10(1):87. doi: 10.1186/s13073-018-0598-2.
2
Long-Term Survival of Patients With Melanoma With Active Brain Metastases Treated With Pembrolizumab on a Phase II Trial.在一项 II 期临床试验中，接受派姆单抗治疗的有活性脑转移的黑色素瘤患者的长期生存情况。
J Clin Oncol. 2019 Jan 1;37(1):52-60. doi: 10.1200/JCO.18.00204. Epub 2018 Nov 8.
3
Treatment of brain metastases with stereotactic radiosurgery and immune checkpoint inhibitors: An international meta-analysis of individual patient data.立体定向放射外科和免疫检查点抑制剂治疗脑转移瘤：一项国际单患者数据荟萃分析。
Radiother Oncol. 2019 Jan;130:104-112. doi: 10.1016/j.radonc.2018.08.025. Epub 2018 Sep 18.
4
Management of metastatic melanoma: improved survival in a national cohort following the approvals of checkpoint blockade immunotherapies and targeted therapies.转移性黑色素瘤的治疗：在批准检查点阻断免疫疗法和靶向治疗后，国家队列的生存率得到提高。
Cancer Immunol Immunother. 2018 Dec;67(12):1833-1844. doi: 10.1007/s00262-018-2241-x. Epub 2018 Sep 6.
5
Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain.纳武利尤单抗联合伊匹单抗治疗脑转移黑色素瘤。
N Engl J Med. 2018 Aug 23;379(8):722-730. doi: 10.1056/NEJMoa1805453.
6
Improved Risk-Adjusted Survival for Melanoma Brain Metastases in the Era of Checkpoint Blockade Immunotherapies: Results from a National Cohort.免疫检查点阻断治疗时代黑素瘤脑转移的风险调整后生存率提高：一项全国性队列研究的结果。
Cancer Immunol Res. 2018 Sep;6(9):1039-1045. doi: 10.1158/2326-6066.CIR-18-0067. Epub 2018 Jul 12.
7
Safety and efficacy of nivolumab for metastatic renal cell carcinoma: real-world results from an expanded access programme.纳武利尤单抗治疗转移性肾细胞癌的安全性和疗效：扩展准入计划的真实世界结果。
BJU Int. 2019 Jan;123(1):98-105. doi: 10.1111/bju.14461. Epub 2018 Jul 23.
8
Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study.纳武利尤单抗联合伊匹单抗或纳武利尤单抗单药治疗黑色素瘤脑转移瘤：一项多中心随机 2 期研究。
Lancet Oncol. 2018 May;19(5):672-681. doi: 10.1016/S1470-2045(18)30139-6. Epub 2018 Mar 27.
9
Cancer immunotherapy using checkpoint blockade.使用免疫检查点阻断的癌症免疫疗法。
Science. 2018 Mar 23;359(6382):1350-1355. doi: 10.1126/science.aar4060. Epub 2018 Mar 22.
10
Concurrent Immune Checkpoint Inhibitors and Stereotactic Radiosurgery for Brain Metastases in Non-Small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma.同步免疫检查点抑制剂和立体定向放射外科治疗非小细胞肺癌、黑色素瘤和肾细胞癌的脑转移。
Int J Radiat Oncol Biol Phys. 2018 Mar 15;100(4):916-925. doi: 10.1016/j.ijrobp.2017.11.041. Epub 2017 Dec 5.

Efficacy and safety of immune checkpoint blockade for brain metastases.

作者信息

Harary Maya, Reardon David A, Iorgulescu J Bryan

机构信息

Harvard Medical School, Boston, MA, 02215, USA.

Department of Neurosurgery, Computational Neuroscience Outcomes Center, Brigham & Women's Hospital, Boston, MA, 02215, USA.

出版信息

CNS Oncol. 2019 Jun;8(2):CNS33. doi: 10.2217/cns-2018-0018. Epub 2019 Mar 11.

DOI:10.2217/cns-2018-0018
PMID:30854898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6713022/
Abstract
摘要