Anatchkova Milena, Brooks Anne, Swett Laura, Hartry Ann, Duffy Ruth A, Baker Ross A, Hammer-Helmich Lene, Sanon Aigbogun Myrlene
Patient Centered Research, Evidera, Bethesda, MD, USA.
Health Economics and Outcomes Research, Lundbeck LLC, Deerfield, IL, USA.
Int Psychogeriatr. 2019 Sep;31(9):1305-1318. doi: 10.1017/S1041610218001898. Epub 2019 Mar 11.
More than 90% of individuals with Alzheimer's disease (AD) experience behavioral and neuropsychiatric symptoms (NPS), such as agitation. However, little is known regarding the specific burden of agitation for Alzheimer's patients.
A global systematic literature review was conducted in MEDLINE and Embase for studies of clinical, humanistic, and economic burden of agitation in AD/dementia published from 2006-2016. References of identified papers and related literature reviews were examined. Studies meeting predetermined inclusion criteria for burden of agitation/NPS were summarized.
Eighty papers met the inclusion criteria for burden of agitation in dementia. Wide ranges of agitation prevalence were reported, but few papers provided information on incidence. The association of agitation with AD severity was presented in multiple studies; a few suggested positive association of agitation with mortality.
High prevalence of agitation is consistent with earlier reports, but several gaps in understanding of agitation in AD need further exploration.
超过90%的阿尔茨海默病（AD）患者会出现行为和神经精神症状（NPS），如激越。然而，对于AD患者激越的具体负担知之甚少。
在MEDLINE和Embase数据库中进行了一项全球系统性文献综述，以研究2006年至2016年发表的有关AD/痴呆中激越的临床、人文和经济负担的研究。对已识别论文的参考文献及相关文献综述进行了审查。对符合激越/NPS负担预定纳入标准的研究进行了总结。
80篇论文符合痴呆中激越负担的纳入标准。报道的激越患病率范围广泛，但很少有论文提供发病率信息。多项研究呈现了激越与AD严重程度的关联；少数研究表明激越与死亡率呈正相关。
激越的高患病率与早期报告一致，但在AD激越的理解方面仍存在一些差距，需要进一步探索。
