[Antithrombotic approaches in patients undergoing left atrial appendage occlusion: current evidence and future perspectives].

Percutaneous left atrial appendage occlusion is a novel therapeutic option for stroke prevention in patients with atrial fibrillation and contraindication to oral anticoagulant therapy. However, after left atrial appendage occlusion with the most commonly used devices, a short period of antithrombotic therapy is indicated to allow complete endothelialization of the device and to prevent device thrombosis. Post-procedure antithrombotic strategies are often performed empirically, because of the lack of clear evidence. The present article summarizes the main evidence and recommendations of the scientific societies about antithrombotic therapy after percutaneous left atrial appendage occlusion, suggesting individualized antithrombotic strategies based on the patient's hemorrhagic and thrombotic risk.