许多被诊断为与医疗保健相关的艰难梭菌感染的患者在入院时是否定植了感染菌株？
Are Many Patients Diagnosed With Healthcare-associated Clostridioides difficile Infections Colonized With the Infecting Strain on Admission?
机构信息
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland Clinic Foundation, Ohio.
Department of Medicine, Cleveland Clinic Foundation, Ohio.
出版信息
Clin Infect Dis. 2019 Oct 30;69(10):1801-1804. doi: 10.1093/cid/ciz189.
PMID:30855075
Abstract
In a cohort of 480 patients admitted to an acute care hospital, 68 (14%) had positive perirectal cultures for toxigenic Clostridioides difficile on admission. Of the 11 patients (2%) diagnosed with healthcare-associated C. difficile infections, 3 (27%) had genetically related admission and infection isolates, based on whole-genome sequencing.
摘要
在一个入住急性护理医院的 480 名患者队列中，68 名（14%）患者在入院时直肠周围培养出产毒艰难梭菌阳性。在 11 名（2%）诊断为与医疗保健相关的艰难梭菌感染的患者中，基于全基因组测序，有 3 名（27%）患者的入院和感染分离株具有遗传相关性。
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