已有全抗毒素 B IgG 免疫对复发性艰难梭菌感染结局的影响。
The impact of existing total anti-toxin B IgG immunity in outcomes of recurrent Clostridioides difficile infection.
机构信息
University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
University of Virginia, Department of Medicine/ Infectious Disease and International Health, USA.
出版信息
Anaerobe. 2024 Jun;87:102842. doi: 10.1016/j.anaerobe.2024.102842. Epub 2024 Mar 28.
Abstract
Late anti-toxin-B humoral immunity acquired after treatment is important for preventing recurrent Clostridioides difficile infection. We prospectively-measured anti-toxin-B IgG and neutralization titers at diagnosis as potential early predictors of recurrence. High anti-toxin-B-IgG/neutralizing antibodies were associated with short-lasting protection within 6-weeks, however, no difference in recurrence risk was observed by 90-days post-infection.
摘要
治疗后获得的晚期抗毒素 B 体液免疫对于预防复发性艰难梭菌感染很重要。我们前瞻性地测量了诊断时的抗毒素 B IgG 和中和效价，作为复发的潜在早期预测指标。高抗毒素 B-IgG/中和抗体与 6 周内的短期保护相关，但在感染后 90 天，复发风险没有差异。
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