Department of Psychiatry, Washington University School of Medicine, St. Louis, MO.
Nicotine Tob Res. 2020 Feb 6;22(2):147-151. doi: 10.1093/ntr/ntz036.
Large segments of the world population use combustible cigarettes, and our society pays a high price for smoking, through increased healthcare expenditures, morbidity and mortality. The development of combustible cigarette smoking requires the initiation of smoking and a subsequent chain of behavioral transitions from experimental use, to established regular use, to the conversion to addiction. Each transition is influenced by both environmental and genetic factors, and our increasing knowledge about genetic contributions to smoking behaviors opens new potential interventions.
This review describes the journey from genetic discovery to the potential implementation of genetic knowledge for the treatment of tobacco use disorder.
The field of genetics applied to smoking behaviors has rapidly progressed with the identification of highly validated genetic variants that are associated with different smoking behaviors. The large scale implementation of this genetic knowledge to accelerate smoking cessation represents an important clinical challenge in precision medicine.
世界上很大一部分人口使用可燃香烟，我们的社会为吸烟付出了高昂的代价，包括增加医疗保健支出、发病率和死亡率。可燃香烟的发展需要吸烟的开始，以及随后从实验使用、到既定的定期使用、再到成瘾的行为转变的链条。每个转变都受到环境和遗传因素的影响，我们对遗传因素对吸烟行为的贡献的认识不断增加，为新的潜在干预措施开辟了道路。
本综述描述了从遗传发现到潜在实施遗传知识治疗烟草使用障碍的过程。
应用于吸烟行为的遗传学领域取得了快速进展，已经确定了与不同吸烟行为相关的高度验证的遗传变异。大规模实施这种遗传知识以加速戒烟是精准医学面临的一个重要临床挑战。
