利用精准医学时代的基因组数据进行戒烟临床试验：原因与方法。
Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.
机构信息
Siteman Cancer Center, Institute of Public Health, and Department of Psychiatry, Washington University School of Medicine, St. Louis, MI.
Nicotine Dependence Service, Centre for Addiction and Mental Health, and Dept. of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
出版信息
Nicotine Tob Res. 2018 Mar 6;20(4):414-424. doi: 10.1093/ntr/ntx097.
Abstract
This article outlines a framework for the consistent integration of biological data/samples into smoking cessation pharmacotherapy trials, aligned with the objectives of the recently unveiled Precision Medicine Initiative. Our goal is to encourage and provide support for treatment researchers to consider biosample collection and genotyping their existing samples as well as integrating genetic analyses into their study design in order to realize precision medicine in treatment of nicotine dependence.
摘要
本文概述了一个框架，用于将生物数据/样本与戒烟药物治疗试验进行一致整合，以符合最近公布的精准医学计划的目标。我们的目标是鼓励和支持治疗研究人员考虑收集生物样本并对其现有样本进行基因分型，以及将遗传分析纳入其研究设计，从而在治疗尼古丁依赖方面实现精准医学。
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