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本文引用的文献

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Smokescreen: a targeted genotyping array for addiction research.烟幕：一种用于成瘾研究的靶向基因分型阵列
BMC Genomics. 2016 Feb 27;17:145. doi: 10.1186/s12864-016-2495-7.
2
Enhancing the effectiveness of smoking treatment research: conceptual bases and progress.提高吸烟治疗研究的有效性：概念基础与进展。
Addiction. 2016 Jan;111(1):107-16. doi: 10.1111/add.13154. Epub 2015 Nov 19.
3
Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.药物遗传学等位基因命名法：检测结果报告的国际工作组建议
Clin Pharmacol Ther. 2016 Feb;99(2):172-85. doi: 10.1002/cpt.280. Epub 2015 Nov 20.
4
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.一项关于尼古丁代谢生物标志物的全基因组关联研究。
PLoS Genet. 2015 Sep 25;11(9):e1005498. doi: 10.1371/journal.pgen.1005498. eCollection 2015.
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Behavioral Counseling and Pharmacotherapy Interventions for Tobacco Cessation in Adults, Including Pregnant Women: A Review of Reviews for the U.S. Preventive Services Task Force.行为咨询和药物治疗干预措施在成人中戒烟，包括孕妇：美国预防服务工作组的系统评价综述。
Ann Intern Med. 2015 Oct 20;163(8):608-21. doi: 10.7326/M15-0171. Epub 2015 Sep 22.
6
Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation.基因变异（CHRNA5）、药物治疗（联合尼古丁替代疗法与伐尼克兰）与戒烟
Drug Alcohol Depend. 2015 Sep 1;154:278-82. doi: 10.1016/j.drugalcdep.2015.06.022. Epub 2015 Jun 23.
7
A new initiative on precision medicine.一项关于精准医学的新倡议。
N Engl J Med. 2015 Feb 26;372(9):793-5. doi: 10.1056/NEJMp1500523. Epub 2015 Jan 30.
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Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial.使用尼古丁代谢物比率作为对尼古丁贴片或伐尼克兰戒烟反应的遗传信息生物标志物：一项随机、双盲、安慰剂对照试验。
Lancet Respir Med. 2015 Feb;3(2):131-138. doi: 10.1016/S2213-2600(14)70294-2. Epub 2015 Jan 12.
9
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Transl Behav Med. 2014 Sep;4(3):238-51. doi: 10.1007/s13142-013-0239-7.
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Translating genomics for precision cancer medicine.将基因组学转化用于精准癌症医学。
Annu Rev Genomics Hum Genet. 2014;15:395-415. doi: 10.1146/annurev-genom-090413-025552.

利用精准医学时代的基因组数据进行戒烟临床试验：原因与方法。

Leveraging Genomic Data in Smoking Cessation Trials in the Era of Precision Medicine: Why and How.

机构信息

Siteman Cancer Center, Institute of Public Health, and Department of Psychiatry, Washington University School of Medicine, St. Louis, MI.

Nicotine Dependence Service, Centre for Addiction and Mental Health, and Dept. of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

出版信息

Nicotine Tob Res. 2018 Mar 6;20(4):414-424. doi: 10.1093/ntr/ntx097.

DOI:10.1093/ntr/ntx097
PMID:28498934
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5896450/
Abstract

This article outlines a framework for the consistent integration of biological data/samples into smoking cessation pharmacotherapy trials, aligned with the objectives of the recently unveiled Precision Medicine Initiative. Our goal is to encourage and provide support for treatment researchers to consider biosample collection and genotyping their existing samples as well as integrating genetic analyses into their study design in order to realize precision medicine in treatment of nicotine dependence.

摘要

本文概述了一个框架，用于将生物数据/样本与戒烟药物治疗试验进行一致整合，以符合最近公布的精准医学计划的目标。我们的目标是鼓励和支持治疗研究人员考虑收集生物样本并对其现有样本进行基因分型，以及将遗传分析纳入其研究设计，从而在治疗尼古丁依赖方面实现精准医学。