Maia C, Costa A, Abreu P, Sa M J
Hospital de Sao Joao, 4200-351 Porto, Portugal.
Universidade do Porto, Porto, Portugal.
Rev Neurol. 2019 Mar 16;68(6):229-235. doi: 10.33588/rn.6806.2018281.
There is poor knowledge on current hospitalizations in the multiple sclerosis (MS) population. The purpose of this study was to determine hospitalization causes and outcomes in a MS hospital-based cohort.
A retrospective chart review was performed on all patients admitted at our centre between August, 2009 and July, 2015, excluding those with no previous established diagnosis.
308 hospitalizations were included, representing a total of 155 patients (female, 67.5%). Median age at hospitalizations was 47 years, with median disease duration of 12 years. The most common overall reason for hospitalization was infectious diseases (22.1%), followed by MS relapses (12.7%) and neurogenic bladder (11%). The median length of hospitalization for all patients was 5 days and the progressive subtype of MS had longer lengths of hospitalization than the relapsing-remitting MS. Intensive care unit admission occurred in 23 cases (7.5%) and were associated with increased mortality and length of hospitalization. Of the 308 hospitalizations, 9 (2.9%) resulted in death.
Infections are the most common cause of hospitalizations in our study, although MS relapses or complications related to MS continue to be significant causes of morbidity. Almost 8% of all MS hospitalizations required intensive care unit admission and these were related to longer admission lengths and higher death rates.
对于目前多发性硬化症（MS）患者的住院情况了解不足。本研究的目的是确定以医院为基础的MS队列中的住院原因及结局。
对2009年8月至2015年7月期间在我们中心住院的所有患者进行回顾性病历审查，排除既往未确诊的患者。
纳入308次住院病例，共155例患者（女性占67.5%）。住院时的中位年龄为47岁，疾病中位病程为12年。住院最常见的总体原因是感染性疾病（22.1%），其次是MS复发（12.7%）和神经源性膀胱（11%）。所有患者的中位住院时间为5天，MS的进展型亚型的住院时间比复发缓解型MS更长。23例（7.5%）患者入住重症监护病房，且与死亡率增加和住院时间延长相关。在308次住院病例中，9例（2.9%）导致死亡。
在我们的研究中，感染是住院最常见的原因，尽管MS复发或与MS相关的并发症仍然是发病的重要原因。几乎8%的MS住院患者需要入住重症监护病房，且这些与更长的住院时间和更高的死亡率相关。
