Iwanaga T, Furukawa H
Gan To Kagaku Ryoho. 1986 May;13(5):1962-9.
A literature survey was conducted regarding adjuvant therapy for surgical cases of gastric cancer. A total of 66 papers published on a world wide basis in the 5 years from 1980 through 1984 were collected. Forty-three papers (65%) were published by Japanese researchers, of which only 17 were written in English. Adjuvant therapy was regarded as being effective in about 60% of the papers. The main drugs achieving effective adjuvant chemotherapy were mitomycin C (M), 5-FU (F), Tegafur, MF, and MFC(M+F+cytosine arabinoside). The cases yielding an effective result were mainly patients who had undergone radical surgery for stage II or III gastric cancer. The doses used for adjuvant chemotherapy were slightly less than the doses used for chemotherapy of advanced gastric cancer in internal medicine. The incidences of adverse effects of the adjuvant chemotherapy were almost the same as those encountered in internal medicine, and severe complications occasionally developed. Some recent reports observed that efficacy of adjuvant chemotherapy was increased by intensive therapy in the immediate postoperative period and by maintenance therapy over the long term.
针对胃癌手术病例的辅助治疗进行了文献调查。收集了1980年至1984年这5年间在全球发表的共计66篇论文。其中43篇（65%）由日本研究人员发表，其中只有17篇是英文撰写的。约60%的论文认为辅助治疗有效。实现有效辅助化疗的主要药物有丝裂霉素C（M）、5-氟尿嘧啶（F）、替加氟、MF和MFC（M+F+阿糖胞苷）。产生有效结果的病例主要是接受了II期或III期胃癌根治性手术的患者。辅助化疗所用剂量略低于内科晚期胃癌化疗的剂量。辅助化疗的不良反应发生率与内科所见几乎相同，偶尔会出现严重并发症。一些近期报告指出，术后即刻强化治疗和长期维持治疗可提高辅助化疗的疗效。
