Nakajima T, Takahashi T, Takagi K, Kuno K, Kajitani T
Gan No Rinsho. 1983 Aug;29(10):1229-36.
From a retrospective analysis of 1,169 cases of gastric cancer treated with curative gastrectomy and randomized controlled adjuvant chemotherapy of six different protocols from 1961 to 1981, good candidates for adjuvant chemotherapy were found to be those who had lymphatic spread of n1 to n2 or serosal involvement of S1 to S2 or stage II or III diseases. Multidrug combination therapy produced better survival than single drug therapy. Long term oral maintenance therapy was not yet concluded to be essential for the adjuvant chemotherapy of gastric cancer. Patients with relatively late stage disease should be treated earlier than two weeks after surgery.
通过对1961年至1981年期间接受根治性胃切除术及六种不同方案随机对照辅助化疗的1169例胃癌病例进行回顾性分析，发现辅助化疗的良好候选者为那些存在n1至n2淋巴结转移、S1至S2浆膜受累或处于II期或III期疾病的患者。联合化疗比单一药物治疗产生了更好的生存率。对于胃癌的辅助化疗，尚未得出长期口服维持治疗至关重要的结论。疾病分期相对较晚的患者应在术后两周内尽早接受治疗。
