Department of Imaging Diagnosis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Xray Sci Technol. 2019;27(3):493-502. doi: 10.3233/XST-180462.
To retrospectively explore correlation of the resected specimen volume of breast microcalcification lesions and endogenous and exogenous factors of stereotactic needle localization biopsy (SNLB).
Totally 214 patients underwent SNLB for non-palpable breast lesion with microcalcification lesions. Of 211 patients, 198 patients underwent single needle localization and 13 patients underwent multi-needle localization (26 lesions). Lesion sizes, distribution characteristics, lesion localization accuracy and resected specimen volumes were recorded and analyzed using a generalized linear model (GLM).
The average lesion diameter is 2.63±1.73 cm. The localization accuracy of 187 lesions were moderate, 26 were too deep and 11 were too superficial. The mean resected specimen volume (V) was 17.51±5.14 cm3. One-way ANOVA analysis showed that 3 factors, including lesion sizes, distribution characteristics and the localization accuracy were associated with resected specimen volume (F = 67.56-112.78, P < 0.001). GLM revealed that lesion sizes, single clustered distribution and accurate localization were significant factors for resected specimen volume (F = -4.82-11.36, P < 0.05). The ratio (%) of the resected specimen volume to the involved breast volume (V0) was defined as the degree of breast defect. The mean breast defect of 125 benign patients (V/V0) was 27.5% ranging from 10.1% to 42.3%.
Average lesion diameter and localization accuracy are highly significant variables for the resected specimen volume. Localization accuracy as a subjective controllable variable is one of the important factors that determine the volume of lesion resection. Single clustered distribution was more susceptible localization accuracy than other characteristic distributions. Improving localization accuracy can reduce resected specimen volume, which can reduce breast defect to a certain extent.
回顾性探讨乳腺微钙化病变切除标本体积与立体定向针定位活检（SNLB）的内源性和外源性因素的相关性。
对 214 例因触诊阴性乳腺微钙化病变而行 SNLB 的患者进行回顾性分析。211 例患者行单针定位，13 例患者行多针定位（26 个病灶）。记录并分析病灶大小、分布特征、病灶定位准确性和切除标本体积，采用广义线性模型（GLM）。
平均病灶直径为 2.63±1.73cm。187 个病灶的定位准确率为中度，26 个病灶过深，11 个病灶过浅。平均切除标本体积（V）为 17.51±5.14cm3。单因素方差分析显示，病灶大小、分布特征和定位准确性 3 个因素与切除标本体积相关（F = 67.56-112.78，P < 0.001）。GLM 显示病灶大小、单发簇状分布和准确定位是切除标本体积的显著因素（F = -4.82-11.36，P < 0.05）。切除标本体积与受累乳腺体积（V0）的比值（%）定义为乳腺缺损程度。125 例良性患者的平均乳腺缺损（V/V0）为 27.5%，范围为 10.1%-42.3%。
平均病灶直径和定位准确性是切除标本体积的高度显著变量。定位准确性作为一个主观可控变量，是决定病变切除体积的重要因素之一。单发簇状分布比其他特征分布更易定位准确。提高定位准确性可以减少切除标本体积，在一定程度上减少乳腺缺损。
