八角果实中的化学成分及其抗病毒活性和神经保护作用。
Chemical constituents from the fruits of Illicium simonsii and their antiviral activity and neuroprotective effect.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
出版信息
Phytochemistry. 2022 Oct;202:113323. doi: 10.1016/j.phytochem.2022.113323. Epub 2022 Jul 12.
One undescribed diterpenoid illisimonone A, four undescribed sesquiterpenes named (±)-simonones A, simonterpenoids A and B, and two undescribed lignans, illisimonins A and B, along with five known compounds were isolated from the fruits of Illicium simonsii. Their structures were elucidated by extensive spectroscopic data. The absolute configuration of illisimonone A was determined by single-crystal X-ray diffraction analysis. Illisimonone A showed potential antiviral activity against the Coxsackie B3 virus, with an IC value of 3.70 μM. Illisimonin B and henrylactone A showed potential neuroprotective effects against oxygen-glucose deprivation induced cell injury in SK-N-SH cells, with survival rates of 57.6%, 58.0%, respectively.
从八角属植物八角的果实中分离得到一个新的二萜类化合物illisimonone A，四个新的倍半萜类化合物（±）-simonones A、simonterpenoids A 和 B，以及两个新的木脂素类化合物illisimonins A 和 B，此外还分离得到 5 个已知化合物。通过广泛的光谱数据分析确定了它们的结构。通过单晶 X 射线衍射分析确定了 illisimonone A 的绝对构型。Illisimonone A 对柯萨奇 B3 病毒具有潜在的抗病毒活性，IC 值为 3.70 μM。Illisimonin B 和 henrylactone A 对氧葡萄糖剥夺诱导的 SK-N-SH 细胞损伤具有潜在的神经保护作用，存活率分别为 57.6%和 58.0%。
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