Ragone D J, Kellerman W C, Bonner F J
Arch Phys Med Rehabil. 1986 May;67(5):339-41.
A 26-year-old man manifested clinical signs of a left iliofemoral thrombosis 12 weeks after closed head injury in a motor vehicle accident. The deep vein thrombosis was initially diagnosed by venography and appropriate anticoagulation therapy was instituted. After four days of treatment, there was no significant resolution of signs or symptoms and the circumference of the left thigh had increased with an associated decrease in hemoglobin. A CT scan of the involved thigh revealed hemorrhage and calcification within the quadriceps muscle. In retrospect, it was evident that the hemorrhage and heterotopic ossification had caused compression of the surrounding tissue and vessels thus mimicking a deep vein thrombosis on venography. Clinicians need to be aware of the similarity of the early clinical manifestations of heterotopic ossifications and deep vein thrombosis and the complications which could arise with anticoagulation therapy initiated too early in the course of the disease.
一名26岁男性在机动车事故中头部闭合性损伤12周后，出现左髂股静脉血栓形成的临床症状。深静脉血栓形成最初通过静脉造影诊断，并开始进行适当的抗凝治疗。治疗四天后，体征或症状无明显缓解，左大腿周长增加，血红蛋白相应下降。受累大腿的CT扫描显示股四头肌内有出血和钙化。回顾来看，很明显出血和异位骨化导致了周围组织和血管受压，从而在静脉造影上模拟了深静脉血栓形成。临床医生需要意识到异位骨化和深静脉血栓形成早期临床表现的相似性，以及在疾病过程中过早开始抗凝治疗可能出现的并发症。
