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头发皮质醇、一生创伤经历与无人陪伴难民未成年的精神病理学。

Hair cortisol, lifetime traumatic experiences and psychopathology in unaccompanied refugee minors.

机构信息

Department for Medical Psychology and Medical Sociology, University of Leipzig, Germany.

Department for Medical Psychology and Medical Sociology, University of Leipzig, Germany.

出版信息

Psychoneuroendocrinology. 2019 Jun;104:191-194. doi: 10.1016/j.psyneuen.2019.03.003. Epub 2019 Mar 6.

Abstract

Attenuated cortisol secretion has been linked to traumatic experiences and the developmental psychopathology. Unaccompanied refugee minors (URM) form a highly vulnerable group in this context, usually exposed to multiple and severe traumatic experiences and characterized by a high, comorbid symptom-load. Here, we provide a first investigation in URM seeking to elucidate associations between long-term cortisol output, assessed through hair cortisol concentrations (HCC), lifetime traumatic events and psychological symptoms. Ninety-one male URM from Syria and Afghanistan (mean age = 17.4 years), living in group homes of the Child Protection Services in Leipzig, Germany, were examined. HCC were measured from scalp-near 3 cm hair segments and data on LTE, PTSD symptoms, depression, anxiety and somatic symptoms as well as emotional and conduct problems assessed. Results revealed HCC to be negatively related to lifetime traumatic events (total number, trauma types). In addition, a tentative finding of a positive association between HCC and emotional problems emerged. Results are discussed with regard to their relevance for HCC as a biomarker of the long-term endocrine consequences of chronic adversity and trauma exposure.

摘要

皮质醇分泌减弱与创伤经历和发展心理病理学有关。在这种情况下,无人陪伴的未成年难民(URM)是一个高度脆弱的群体,他们通常经历多次严重的创伤事件,并表现出高共病症状负荷。在这里,我们对寻求阐明通过头发皮质醇浓度(HCC)评估的长期皮质醇输出与终生创伤事件和心理症状之间关联的 URM 进行了首次调查。91 名来自叙利亚和阿富汗的男性 URM(平均年龄=17.4 岁),居住在德国莱比锡儿童保护服务机构的集体宿舍中,接受了检查。从头皮附近 3 厘米的头发段测量 HCC,并评估了关于 LTE、创伤后应激障碍症状、抑郁、焦虑和躯体症状以及情绪和行为问题的数据。结果表明 HCC 与终生创伤事件(总数、创伤类型)呈负相关。此外,还发现 HCC 与情绪问题之间存在正相关的初步发现。结果将根据 HCC 作为慢性逆境和创伤暴露对长期内分泌后果的生物标志物的相关性进行讨论。

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