血液灌流中所用吸附剂的体外评价（作者译）
[In vitro evaluation of adsorbents used in haemoperfusion (author's transl)].
作者信息
Külpmann W R, Oellerich M, Blume U, Schmidt E, Barthels M
出版信息
Klin Wochenschr. 1978 Dec 1;56(23):1171-8. doi: 10.1007/BF01476861.
The properties of six adsorbents for Haemoperfusion were investigated in vitro: Amberlite XAD-2; Amberlite XAD-4; Haemocol; collodion coated charcoal; albumine-collodion encapsulated charcoal and activated carbon fibers. Carbromal and diazepam are most quickly removed from aqueous solutions by Amberlite XAD-2 and XAD-4. Of the charcoal containing materials, Haemocol eliminates most rapidly carbromal and diazepam; while activated carbon fibers remove phenobarbital faster. When heparinized blood is perfused, a remarkable reduction in platelet count is observed. The drop is most pronounced with Amberlite XAD-2 and XAD-4, but even when using charcoal preparations the platelet depletion can reach 10% of the original number over 5 hours. Haemolysis is most pronounced with Amberlite XAD-2, XAD-4 and Haemocol. As the efficiency of the adsorbents towards the various drugs differ and as their adverse effects also vary, the decision for a particular material will have to be made according to the individual case.
对六种用于血液灌流的吸附剂的性能进行了体外研究
Amberlite XAD - 2；Amberlite XAD - 4；血碳；火棉胶包裹炭；白蛋白 - 火棉胶包囊炭和活性炭纤维。Amberlite XAD - 2和XAD - 4能最快地从水溶液中去除卡溴脲和地西泮。在含炭材料中，血碳去除卡溴脲和地西泮的速度最快；而活性炭纤维去除苯巴比妥的速度更快。当灌注肝素化血液时，观察到血小板计数显著降低。Amberlite XAD - 2和XAD - 4导致的血小板计数下降最为明显，但即使使用炭制剂，5小时内血小板减少量也能达到原始数量的10%。Amberlite XAD - 2、XAD - 4和血碳导致的溶血最为明显。由于吸附剂对各种药物的吸附效率不同，且它们的不良反应也有所差异，因此必须根据具体情况选择特定的材料。
Zotero 插件