血液灌流材料从人血浆中去除真菌毒素奥来毒素的效率。

Efficiency of haemoperfusion materials at removing the fungal toxin orellanine from human plasma.

作者信息

Fulde K, Böhler J, Keller E, Frahm A W

机构信息

Department of Pharmaceutical Chemistry, University of Freiburg, Germany.

出版信息

Pharmazie. 1998 Jan;53(1):58-9.

PMID:9476259

Abstract

Orellanine is the main toxin of various Cortinarius mushrooms and responsible for their nephrotoxicity. The present study was undertaken to estimate the value of haemoperfusion in Cortinarius intoxications. The efficiency of the haemoperfusion materials activated charcoal (DHP-1) and Amberlite XAD 4 resin at removing orellanine from plasma was tested in an in vitro model. Quantification of the toxin in plasma samples was carried out following a previously reported fluorodensitometric TLC method. Orellanine is sufficiently bound to both haemoperfusion materials. However, the rate of orellanine adsorption was four times higher on activated charcoal (DHP-1) compared to Amberlite XAD 4 resin.

摘要

奥来毒素是多种丝膜菌属蘑菇的主要毒素，也是其肾毒性的罪魁祸首。本研究旨在评估血液灌流在丝膜菌中毒治疗中的价值。在体外模型中测试了血液灌流材料活性炭（DHP-1）和Amberlite XAD 4树脂从血浆中去除奥来毒素的效率。血浆样品中的毒素定量采用先前报道的荧光密度薄层色谱法进行。奥来毒素与两种血液灌流材料都有充分的结合。然而，活性炭（DHP-1）对奥来毒素的吸附率是Amberlite XAD 4树脂的四倍。