Harstick K, Holloway C J, Brunner G, Külpmann W R, Petry K
Int J Artif Organs. 1979 Mar;2(2):87-95.
The adsorptive capacities of some ion-exchange resins and activated charcoal towards the hypnotic drugs, phenobarbital, glutethimide, carbromal, and methaqualone, have been investigated. Furthermore, the properties of some of these resins and charcoal, encapsulated in an agarose matrix in the form of beads, have been compared with those of the adsorbent phases in their native states. In general, the adsorptive capacities of charcoal were at least as good as, and frequently better than those of the resins. Amberlite XAD-type resins had a higher affinity than Dowex-type resins for all the drugs tested, except for phenobarbital, which was not adsorbed to a satisfactory extent onto Amberlite XAD-4. The encapsulation of adsorbent phases into agarose beads of diameter 5-10 mm results in a reduction of the adsorbtion of the drugs. Nonetheless, the remaining adsorptive capacity is sufficient for application in an extracorporeal detoxification system. Moreover, the overwhelming advantage of good haemocompatibility is provided by the agarose-encapsulated adsorbents.
研究了一些离子交换树脂和活性炭对催眠药物苯巴比妥、格鲁米特、溴米那普鲁卡因和甲喹酮的吸附能力。此外，还将其中一些以珠状形式封装在琼脂糖基质中的树脂和活性炭的性能与它们天然状态下的吸附剂相的性能进行了比较。一般来说，活性炭的吸附能力至少与树脂相当，而且常常比树脂更好。除苯巴比妥外，Amberlite XAD型树脂对所有测试药物的亲和力都高于Dowex型树脂，苯巴比妥在Amberlite XAD - 4上的吸附程度不尽人意。将吸附剂相封装到直径为5 - 10毫米的琼脂糖珠中会导致药物吸附量减少。尽管如此，剩余的吸附能力足以应用于体外解毒系统。此外，琼脂糖封装的吸附剂具有良好的血液相容性这一压倒性优势。
