Mel'kumiants A M, Balashov T A, Smishko V, Khaiutin V M
Biull Eksp Biol Med. 1986 May;101(5):524-6.
The possibility of selective blockade of arterial sensitivity to flow rate was investigated. The method under study was based on the ability of glutaraldehyde to increase cellular rigidity. As flow-induced arterial dilatation depends on endothelial sensitivity to force, the increased rigidity of endothelial cells leads to the reduction of the dilator stimulus. It was shown that the treatment of endothelium with dimerized glutaraldehyde (0.01-0.03%, 30 sec) removed flow-induced arterial dilatation, without abolishing acetylcholine-evoked dilatation.
研究了选择性阻断动脉对流速敏感性的可能性。所研究的方法基于戊二醛增加细胞刚性的能力。由于血流诱导的动脉扩张取决于内皮对力的敏感性，内皮细胞刚性的增加导致扩张刺激的减少。结果表明，用二聚化戊二醛（0.01 - 0.03%，30秒）处理内皮可消除血流诱导的动脉扩张，而不消除乙酰胆碱诱发的扩张。
