两种具有抗菌活性的新型吩嗪代谢物来自土壤来源的链霉菌属。

Two new phenazine metabolites with antimicrobial activities from soil-derived Streptomyces species.

机构信息

Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, College of Life Science, Yunnan University, 650091, Kunming, China.

Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, 110819, Shenyang, China.

出版信息

J Antibiot (Tokyo). 2019 Jul;72(7):574-577. doi: 10.1038/s41429-019-0163-2. Epub 2019 Mar 11.

DOI:10.1038/s41429-019-0163-2

PMID:30858498

Abstract

Two new phenazine metabolites, 6-hydroxyphenazine-1-carboxamide (1) and methyl 6-carbamoylphenazine-1-carboxylate (2), were isolated from a soil-derived Streptomyces diastaticus subsp. ardesiacus strain YIM PH20246, and their structures were elucidated by extensive spectroscopic data analysis. The antimicrobial activities of the isolates were assayed. Compound 1 showed moderate antifungal and antibacterial activities against Fusarium oxysporum (ATCC 7808), Fusarium solani (ATCC 36031) and Plectosphaerella cucumerina (local isolate), Staphylococcus aureus (ATCC 25923) and Staphylococcus albus (ATCC 10231), respectively. Compound 2 exhibited moderate antifungal and antibacterial activities against F. oxysporum, F. solani, and Phoma herbarum, S. aureus, S. albus, and Bacillus subtilis, respectively.

摘要

从一株土壤来源的解淀粉链霉菌亚种（Streptomyces diastaticus subsp. ardesiacus）菌株 YIM PH20246 中分离得到两个新的吩嗪代谢产物：6-羟基吩嗪-1-甲酰胺（1）和 6-甲酰胺基吩嗪-1-羧酸甲酯（2），并通过广泛的光谱数据分析阐明了它们的结构。对分离物的抗菌活性进行了测定。化合物 1 对尖孢镰刀菌（Fusarium oxysporum）（ATCC 7808）、茄病镰刀菌（Fusarium solani）（ATCC 36031）和瓜亡革菌（Plectosphaerella cucumerina）（当地分离株）、金黄色葡萄球菌（Staphylococcus aureus）（ATCC 25923）和白色葡萄球菌（Staphylococcus albus）（ATCC 10231）表现出中等的抗真菌和抗菌活性。化合物 2 对尖孢镰刀菌、茄病镰刀菌和叶点霉，金黄色葡萄球菌、白色葡萄球菌和枯草芽孢杆菌分别表现出中等的抗真菌和抗菌活性。