Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, College of Life Science , Yunnan University , Kunming 650091 , China.
Institute of Microbial Pharmaceuticals, College of Life and Health Sciences , Northeastern University , Shenyang 110819 , China.
J Agric Food Chem. 2019 Oct 16;67(41):11403-11407. doi: 10.1021/acs.jafc.9b04191. Epub 2019 Oct 7.
Three new phenazine metabolites, strepphenazine A-C (), along with a known compound baraphenazine E were isolated from the culture broth of a strain YIM PH20095. The structures were elucidated based on the spectral data. Compounds showed different antifungal activity against , , , and , which caused root-rot disease of with minimal inhibitory concentrations (MICs) of 16-64 μg/mL; compared with compound , compounds showed better antifungal activity against some of these pathogenic fungi with MICs of 16-32 μg/mL, while compound showed antifungal activity against , , and with the same MICs of 64 μg/mL. Thus, strain YIM PH20095 provides new sources for the development of biological control agents to prevent the infection of pathogenic fungi of .
从一株 菌 YIM PH20095 的发酵液中分离得到 3 个新的吩嗪类代谢产物 strepphenazine A-C ()，并结合波谱数据鉴定了它们的结构。化合物 对引起 根腐病的 、 、 和 表现出不同的抗真菌活性，最小抑菌浓度（MICs）为 16-64μg/mL；与化合物 相比，化合物 对部分病原菌的抗真菌活性更好，MICs 为 16-32μg/mL，而化合物 对 、 和 的 MICs 相同，均为 64μg/mL。因此，菌株 YIM PH20095 为开发生物防治剂以防止病原菌感染提供了新的资源。
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